ArticleDer Internist2008
[Therapy and prophylaxis of infective endocarditis].
Article in Der Internist, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- [Septic arthritis as an initial manifestation of a bacterial endocarditis].Der Unfallchirurg · 2013Article
- [Management of cardiac high risk pregnancy. Caesarean section in a primagravida with cyanotic cardiac defect].Der Anaesthesist · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis is an infection of cardiovascular structures which is typically caused by bacteria. Despite recent medical advances mortality ranges from 20 to 25%. Without treatment, IE is a lethal disease. The mortality rate depends on several clinical factors including the causative microorganism, the time of diagnosis, and the initiation of an adequate therapeutic regimen. The diagnosis is based on positive blood culture results with identical microorganisms and the demonstration of endocardial involvement. Negative blood cultures represent a diagnostic challenge which may increase the importance of diagnostic tools such as serology and PCR. An early and targeted initiation of an antibiotic therapy after microbiologic testing is crucial for therapeutic success. The immediate cooperation of Cardiologists, Microbiologists, Infectious Disease Specialists and Cardiac Surgeons is highly recommended to allow an adequate medical and surgical treatment in complex cases.Prophylaxis appears reasonable due to the inherent high mortality. The efficacy of an antibiotic prophylaxis is, nevertheless, not rigorously proven. Even if a high efficacy is assumed, the number needed to treat is extremely high due to the low individual risk. Thus, current guidelines recommend an antibiotic prophylaxis only in patients with a high risk for an adverse outcome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.