ArticlePloS one2008
ES-cell derived hematopoietic cells induce transplantation tolerance.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Tracking embryonic hematopoietic stem cells to the bone marrow: nanoparticle options to evaluate transplantation efficiency.Stem cell research & therapy · 2018Article
- Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation.Experimental & molecular medicine · 2017Article
- Induced pluripotent stem cell-derived gamete-associated proteins incite rejection of induced pluripotent stem cells in syngeneic mice.Immunology · 2017Article
- Identification of early myeloid progenitors as immunosuppressive cells.Scientific reports · 2016Article
- Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation.Stem cells international · 2016Review
- Attenuated Innate Immunity in Embryonic Stem Cells and Its Implications in Developmental Biology and Regenerative Medicine.Stem cells (Dayton, Ohio) · 2015Review
- Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice.PloS one · 2015Article
- Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 ξ chain on T cells, abrogating alloreactive T cells.Immunology · 2014Article
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- The transcriptional landscape of hematopoietic stem cell ontogeny.Cell stem cell · 2012Article
- Embryonic stem cell-derived T cells induce lethal graft-versus-host disease and reject allogenic skin grafts upon thymic selection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- Role of donor-specific regulatory T cells in long-term acceptance of rat hind limb allograft.PloS one · 2012Article
- Immunological applications of stem cells in type 1 diabetes.Endocrine reviews · 2011Review
- Immunity of embryonic stem cell-derived hematopoietic progenitor cells.Seminars in immunopathology · 2011Review
- In vitro immunogenicity of undifferentiated pluripotent stem cells (PSC) and derived lineages.Seminars in immunopathology · 2011Review
- Experimental limitations using reprogrammed cells for hematopoietic differentiation.Journal of biomedicine & biotechnology · 2011Review
- Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.Stem cells (Dayton, Ohio) · 2010Article
- Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.Blood · 2009Article
- HOXB4 but not BMP4 confers self-renewal properties to ES-derived hematopoietic progenitor cells.Transplantation · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone marrow cells induce stable mixed chimerism under appropriate conditioning of the host, mediating the induction of transplantation tolerance. However, their strong immunogenicity precludes routine use in clinical transplantation due to the need for harsh preconditioning and the requirement for toxic immunosuppression to prevent rejection and graft-versus-host disease. Alternatively, embryonic stem (ES) cells have emerged as a potential source of less immunogenic hematopoietic progenitor cells (HPCs). Up till now, however, it has been difficult to generate stable hematopoietic cells from ES cells. METHODOLOGY/PRINCIPAL
findingsHere, we derived CD45(+) HPCs from HOXB4-transduced ES cells and showed that they poorly express MHC antigens. This property allowed their long-term engraftment in sublethally irradiated recipients across MHC barriers without the need for immunosuppressive agents. Although donor cells declined in peripheral blood over 2 months, low level chimerism was maintained in the bone marrow of these mice over 100 days. More importantly, chimeric animals were protected from rejection of donor-type cardiac allografts.
conclusionsOur data show, for the first time, the efficacy of ES-derived CD45(+) HPCs to engraft in allogenic recipients without the use of immunosuppressive agents, there by protecting cardiac allografts from rejection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.