ArticleTransplantation2008
Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings.
Article in Transplantation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- Meningeal cryptococcosis in a pancreas transplant recipient requiring grafectomy: A case report.World journal of gastrointestinal surgery · 2024Article
- Cryptococcosis in kidney transplant recipients: Current understanding and practices.World journal of nephrology · 2023Review
- Non-meningeal, non-pulmonary cryptococcosis with limited posterior uveitis in a kidney organ transplant recipient with antibody-mediated rejection: a case report.BMC ophthalmology · 2023Article
- Neuroimaging of Cryptococcal Meningitis in Patients without Human Immunodeficiency Virus: Data from a Multi-Center Cohort Study.Journal of fungi (Basel, Switzerland) · 2023Article
- Cryptococcal Meningitis in Kidney Transplant Recipients: A Two-Decade Cohort Study in France.Pathogens (Basel, Switzerland) · 2022Article
- Cryptococcus neoformans infection in Human Immunodeficiency Virus (HIV)-infected and HIV-uninfected patients at an inner-city tertiary care hospital in the Bronx.Medical mycology · 2020Article
- Impaired consciousness and decreased glucose concentration of CSF as prognostic factors in immunocompetent patients with cryptococcal meningitis.BMC infectious diseases · 2020Article
- Central Nervous System Cryptococcal Infections in Non-HIV Infected Patients.Journal of fungi (Basel, Switzerland) · 2019Review
- Imaging spectrum of central nervous system complications of hematopoietic stem cell and solid organ transplantation.Neuroradiology · 2017Review
- Predictors of immune reconstitution syndrome in organ transplant recipients with cryptococcosis: implications for the management of immunosuppression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Observational
- Neurological complications of solid organ transplantation.The Neurohospitalist · 2013Article
- Invasive fungal infections in solid organ transplant recipients.Future microbiology · 2012Review
- [Immune reconstitution syndrome].Zeitschrift fur Rheumatologie · 2012Article
- Article
- Identifying predictors of central nervous system disease in solid organ transplant recipients with cryptococcosis.Transplantation · 2010Article
- Concomitant cryptococcosis and burkholderia infection in an asymptomatic lung transplant patient with cystic fibrosis.International journal of organ transplantation medicine · 2010Article
- Lipid formulations of amphotericin B significantly improve outcome in solid organ transplant recipients with central nervous system cryptococcosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Article
Corrections and comments
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Authors and funding
28 authors at 16 institutions in 4 countries.
Funding
Abstract
backgroundPrognostic implications of cryptococcal antigen and outcomes associated with central nervous system (CNS) cryptococcal lesions in solid organ transplant recipients have not been fully defined.
methodsPatients were derived form a cohort of 122 solid organ transplant recipients with cryptococcosis in a multicenter study from 1999 to 2006.
resultsCentral nervous system cryptococcosis was documented in 61 patients. Serum or cerebral spinal fluid antigen titers did not correlate with mortality at 90 days or cerebral spinal fluid sterilization at 2 weeks. Central nervous system lesions were identified in 16 patients and included leptomeningeal lesions in eight, parenchymal lesions in six, and hydrocephalus in two. Overall, 13/16 CNS lesions were present at the time of diagnosis. One parenchymal and two hydrocephalus lesions, however, developed after diagnosis and fulfilled the criteria for immune reconstitution syndrome. Cerebral spinal fluid antigen titers were higher with meningeal versus parenchymal lesions, and hydrocephalus (P=0.015). Mortality was 50% (3/6) for patients with parenchymal, 12.5% (1/8) for those with leptomeningeal, and 0/3 for patients with hydrocephalus. Mortality was 31% (4/13) for patients with CNS lesions at baseline and 0/3 in those with new onset lesions.
conclusionsDespite a higher antigen titer with meningeal lesions, outcomes tended to be worse with parenchymal compared with meningeal lesions or hydrocephalus. New onset CNS lesions may represent immune reconstitution syndrome and seemed to be associated with better outcome.
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Registered trials
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