ArticleGenetics2008
Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
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- A Drosophila melanogaster model for TMEM43-related arrhythmogenic right ventricular cardiomyopathy type 5.Cellular and molecular life sciences : CMLS · 2022Article
- A testis-expressing heme peroxidase HPX12 regulates male fertility in the mosquito Anopheles stephensi.Scientific reports · 2022Article
- Muscle-to-Brain Signaling Via Myokines and Myometabolites.Brain plasticity (Amsterdam, Netherlands) · 2022Review
- Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging.Cell metabolism · 2021Article
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- Beyond Sperm and Male Accessory Gland Proteins: Exploring Insect Reproductive Metabolomes.Frontiers in physiology · 2021Review
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- Changing environments and genetic variation: natural variation in inbreeding does not compromise short-term physiological responses.Proceedings. Biological sciences · 2019Article
- Physiological and Environmental Factors Affecting the Composition of the Ejaculate in Mosquitoes and Other Insects.Insects · 2019Review
- Metabolomic Studies inGenetics · 2017Review
- Selenophosphate synthetase 1 (SPS1) is required for the development and selenium homeostasis of central nervous system in chicken (Gallus gallus).Oncotarget · 2017Article
- Metabolic and functional characterization of effects of developmental temperature in Drosophila melanogaster.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Evolution of the metabolome in response to selection for increased immunity in populations of Drosophila melanogaster.PloS one · 2017Article
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- Metabolomics of aging assessed in individual parasitoid wasps.Scientific reports · 2016Article
- Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity.Neurobiology of aging · 2016Article
- Seasonal cues induce phenotypic plasticity of Drosophila suzukii to enhance winter survival.BMC ecology · 2016Article
- In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury.International journal of molecular medicine · 2016Article
- Entometabolomics: applications of modern analytical techniques to insect studies.Entomologia experimentalis et applicata · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the population genetics of inbreeding is fairly well understood, the effects of inbreeding on the physiological and biochemical levels are not. Here we have investigated the effects of inbreeding on the Drosophila melanogaster metabolome. Metabolite fingerprints in males from five outbred and five inbred lines were studied by nuclear magnetic resonance spectroscopy after exposure to benign temperature, heat stress, or cold stress. In both the absence and the presence of temperature stress, metabolite levels were significantly different among inbred and outbred lines. The major effect of inbreeding was increased levels of maltose and decreased levels of 3-hydroxykynurenine and a galactoside [1-O-(4-O-(2-aminoethyl phosphate)-beta-d-galactopyranosyl)-x-glycerol] synthesized exclusively in the paragonial glands of Drosophila species, including D. melanogaster. The metabolomic effect of inbreeding at the benign temperature was related to gene expression data from the same inbred and outbred lines. Both gene expression and metabolite data indicate that fundamental metabolic processes are changed or modified by inbreeding. Apart from affecting mean metabolite levels, inbreeding led to an increased between-line variation in metabolite profiles compared to outbred lines. In contrast to previous observations revealing interactions between inbreeding and environmental stress on gene expression patterns and life-history traits, the effect of inbreeding on the metabolite profile was similar across the different temperature treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.