ArticleGenetics2008
Evolution of primate gene expression: drift and corrective sweeps?
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Biophysical constraints on mRNA decay rates shape macroevolutionary divergence in steady-state abundances.bioRxiv : the preprint server for biology · 2025Article
- Positive Selection Drives cis-regulatory Evolution Across the Threespine Stickleback Y Chromosome.Molecular biology and evolution · 2024Article
- Toxin expression in snake venom evolves rapidly with constant shifts in evolutionary rates.Proceedings. Biological sciences · 2020Article
- On the specificity of gene regulatory networks: How does network co-option affect subsequent evolution?Current topics in developmental biology · 2020Review
- Drift and Directional Selection Are the Evolutionary Forces Driving Gene Expression Divergence in Eye and Brain Tissue ofGenetics · 2019Article
- Lineage-Specific Expression Divergence in Grasses Is Associated with Male Reproduction, Host-Pathogen Defense, and Domestication.Genome biology and evolution · 2019Article
- Gene Expression Evolves under a House-of-Cards Model of Stabilizing Selection.Molecular biology and evolution · 2015Article
- Sensitivity of quantitative traits to mutational effects and number of loci.Theoretical population biology · 2015Article
- Transcriptomic insights into human brain evolution: acceleration, neutrality, heterochrony.Current opinion in genetics & development · 2014Review
- 8.2% of the Human genome is constrained: variation in rates of turnover across functional element classes in the human lineage.PLoS genetics · 2014Article
- Modeling gene expression evolution with an extended Ornstein-Uhlenbeck process accounting for within-species variation.Molecular biology and evolution · 2014Article
- Phylogenetic analysis using Lévy processes: finding jumps in the evolution of continuous traits.Systematic biology · 2013Article
- Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression.PLoS genetics · 2013Article
- Inferring evolutionary histories of pathway regulation from transcriptional profiling data.PLoS computational biology · 2013Article
- Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The evolution of gene expression and the transcriptome-phenotype relationship.Seminars in cell & developmental biology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 5 countries.
Funding
Abstract
Changes in gene expression play an important role in species' evolution. Earlier studies uncovered evidence that the effect of mutations on expression levels within the primate order is skewed, with many small downregulations balanced by fewer but larger upregulations. In addition, brain-expressed genes appeared to show an increased rate of evolution on the branch leading to human. However, the lack of a mathematical model adequately describing the evolution of gene expression precluded the rigorous establishment of these observations. Here, we develop mathematical tools that allow us to revisit these earlier observations in a model-testing and inference framework. We introduce a model for skewed gene-expression evolution within a phylogenetic tree and use a separate model to account for biological or experimental outliers. A Bayesian Markov chain Monte Carlo inference procedure allows us to infer the phylogeny and other evolutionary parameters, while quantifying the confidence in these inferences. Our results support previous observations; in particular, we find strong evidence for a sustained positive skew in the distribution of gene-expression changes in primate evolution. We propose a "corrective sweep" scenario to explain this phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.