ArticleGenetics2008
Use of a Drosophila model to identify genes regulating Plasmodium growth in the mosquito.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- From Lab to Clinic and Farm: LeveragingBiology · 2025Review
- The Drosophila melanogaster prophenoloxidase system participates in immunity against Zika virus infection.European journal of immunology · 2023Article
- Article
- Predicting host dependency factors of pathogens inComputational and structural biotechnology journal · 2021Article
- OXR2 Increases Plant Defense against a Hemibiotrophic Pathogen via the Salicylic Acid Pathway.Plant physiology · 2020Article
- Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection inJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- TLDc proteins: new players in the oxidative stress response and neurological disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Review
- Heritable strategies for controlling insect vectors of disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Inference of the oxidative stress network in Anopheles stephensi upon Plasmodium infection.PloS one · 2014Article
- Could culicine mosquitoes transmit human malaria?Trends in parasitology · 2013Review
- Parasitoid wasp venom SERCA regulates Drosophila calcium levels and inhibits cellular immunity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections.Infection and immunity · 2012Article
- The Drosophila protein mustard tailors the innate immune response activated by the immune deficiency pathway.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The Drosophila melanogaster host model.Journal of oral microbiology · 2012Article
- A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes.Genetics · 2010Article
- The Anopheles gambiae oxidation resistance 1 (OXR1) gene regulates expression of enzymes that detoxify reactive oxygen species.PloS one · 2010Article
- Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila.PLoS genetics · 2010Article
- Mosquito immune defenses against Plasmodium infection.Developmental and comparative immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We performed a forward genetic screen, using Drosophila as a surrogate mosquito, to identify host factors required for the growth of the avian malaria parasite, Plasmodium gallinaceum. We identified 18 presumed loss-of-function mutants that reduced the growth of the parasite in flies. Presumptive mutation sites were identified in 14 of the mutants on the basis of the insertion site of a transposable element. None of the identified genes have been previously implicated in innate immune responses or interactions with Plasmodium. The functions of five Anopheles gambiae homologs were tested by using RNAi to knock down gene function followed by measuring the growth of the rodent parasite, Plasmodium berghei. Loss of function of four of these genes in the mosquito affected Plasmodium growth, suggesting that Drosophila can be used effectively as a surrogate mosquito to identify relevant host factors in the mosquito.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.