ArticleGenetics2008
Controlling type-I error of the McDonald-Kreitman test in genomewide scans for selection on noncoding DNA.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Convergent evolution of noncoding elements associated with short tarsus length in birds.BMC biology · 2025Article
- Evidence of positive selection and a novel phylogeny among five subspecies of song sparrow (PeerJ · 2025Article
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- A brief history and popularity of methods and tools used to estimate micro-evolutionary forces.Ecology and evolution · 2021Review
- Slow evolution of sex-biased genes in the reproductive tissue of the dioecious plant Salix viminalis.Molecular ecology · 2018Article
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- Analysis of Genetic Variation across the Encapsidated Genome of Microplitis demolitor Bracovirus in Parasitoid Wasps.PloS one · 2016Article
- The effects of natural selection across molecular pathways in Drosophila melanogaster.BMC evolutionary biology · 2015Article
- Variation in promiscuity and sexual selection drives avian rate of Faster-Z evolution.Molecular ecology · 2015Article
- The evolutionary history of SLC6A4 and the role of plasticity in Macaca.American journal of physical anthropology · 2014Article
- Population genomics of the honey bee reveals strong signatures of positive selection on worker traits.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Detecting selection in the blue crab, Callinectes sapidus, using DNA sequence data from multiple nuclear protein-coding genes.PloS one · 2014Article
- Article
- A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers.Molecular biology and evolution · 2013Article
- Mutations within lncRNAs are effectively selected against in fruitfly but not in human.Genome biology · 2013Article
- Frequent adaptation and the McDonald-Kreitman test.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents.PLoS genetics · 2013Article
- Genome-wide characterization of adaptation and speciation in tiger swallowtail butterflies using de novo transcriptome assemblies.Genome biology and evolution · 2013Article
- Allelic imbalance in Drosophila hybrid heads: exons, isoforms, and evolution.Molecular biology and evolution · 2012Article
Corrections and comments
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
Departures from the assumption of homogenously interdigitated neutral and putatively selected sites in the McDonald-Kreitman test can lead to false rejections of the neutral model in the presence of intermediate levels of recombination. This problem is exacerbated by small sample sizes, nonequilibrium demography, recombination rate variation, and in comparisons involving more recently diverged species. I propose that establishing significance levels by coalescent simulation with recombination can improve the fidelity of the test in genomewide scans for selection on noncoding DNA.
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Registered trials
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