ArticleCarcinogenesis2009
Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase.
Article in Carcinogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- PPARγ signaling and emerging opportunities for improved therapeutics.Pharmacological research · 2016Review
- G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY.The Journal of biological chemistry · 2015Article
- Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer.The Journal of steroid biochemistry and molecular biology · 2015Article
- A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.Autophagy · 2014Article
- Endocrine disruption of the epigenome: a breast cancer link.Endocrine-related cancer · 2014Review
- p38 MAPK- and Akt-mediated p300 phosphorylation regulates its degradation to facilitate nucleotide excision repair.Nucleic acids research · 2013Article
- Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.Cancer biology & therapy · 2012Article
- The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells.Environmental health perspectives · 2012Article
- Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance.Oncology reports · 2012Article
- Environmental signaling and reproduction: a comparative biological and chemical perspective.Molecular and cellular endocrinology · 2012Review
- Pharmacology and anti-tumor activity of RWJ67657, a novel inhibitor of p38 mitogen activated protein kinase.American journal of cancer research · 2012Article
- Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.Molecular and cellular biology · 2011Article
- Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer.Journal of molecular endocrinology · 2011Article
- Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.Cancer biology & therapy · 2011Article
- Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.Endocrinology · 2010Article
- Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation.Biological chemistry · 2010Article
- Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The activity of nuclear transcription factors is often regulated by specific kinase-signaling pathways. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). Here, we show that DDT and its metabolites also stimulate the transcriptional activity of cyclic adenosine monophosphate response element-binding protein and Elk1 and potentiate gene expression through cyclic adenosine monophosphate and hypoxia response elements. Because DDT stimulates gene expression through various transcription factors and hence multiple response elements, we hypothesized that p38 signaling targets a common shared transcriptional activator. Here, we demonstrate using both pharmacological and molecular techniques, the general coactivator p300 is phosphorylated and potentiated by the p38 MAPK signaling cascade. We further show that p38 directly phosphorylates p300 in its N-terminus. These results, together with our previous work, suggest that p38 stimulates downstream transcription factors in part by targeting the general coactivator p300.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.