ArticleChemical senses2009
A method for generating natural and user-defined sniffing patterns in anesthetized or reduced preparations.
Article in Chemical senses, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Article
- Article
- Chronic restraint stress impairs sociability but not social recognition and spatial memoryin C57BL/6J mice.Experimental animals · 2019Article
- Inhalation Frequency Controls Reformatting of Mitral/Tufted Cell Odor Representations in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice.Neural plasticity · 2016Article
- An arterially perfused nose-olfactory bulb preparation of the rat.Journal of neurophysiology · 2015Article
- Role of intraglomerular circuits in shaping temporally structured responses to naturalistic inhalation-driven sensory input to the olfactory bulb.Journal of neurophysiology · 2015Article
- Comparing thoracic and intra-nasal pressure transients to monitor active odor sampling during odor-guided decision making in the mouse.Journal of neuroscience methods · 2014Article
- Testing the sorption hypothesis in olfaction: a limited role for sniff strength in shaping primary odor representations during behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Airflow and nanoparticle deposition in rat nose under various breathing and sniffing conditions: a computational evaluation of the unsteady effect.Journal of aerosol science · 2010Article
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Authors and funding
3 authors.
Funding
Abstract
Sniffing has long been thought to play a critical role in shaping neural responses to odorants at multiple levels of the nervous system. However, it has been difficult to systematically examine how particular parameters of sniffing behavior shape odorant-evoked activity, in large part because of the complexity of sniffing behavior and the difficulty in reproducing this behavior in an anesthetized or reduced preparation. Here we present a method for generating naturalistic sniffing patterns in such preparations. The method involves a nasal ventilator whose movement is controlled by an analog command voltage. The command signal may consist of intranasal pressure transients recorded from awake rats and mice or user-defined waveforms. This "sniff playback" device generates intranasal pressure and airflow transients in anesthetized animals that approximate those recorded from the awake animal and are reproducible across trials and across preparations. The device accurately reproduces command waveforms over an amplitude range of approximately 1 log unit and up to frequencies of approximately 12 Hz. Further, odorant-evoked neural activity imaged during sniff playback appears similar to that seen in awake animals. This method should prove useful in investigating how the parameters of odorant sampling shape neural responses in a variety of experimental settings.
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Registered trials
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