ArticleJournal of bacteriology2008
PecS is a global regulator of the symptomatic phase in the phytopathogenic bacterium Erwinia chrysanthemi 3937.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 100 citations in OpenAlex.
- A critical review of natural quorum-sensing inhibitors as molecular anti-virulence agents against phytopathogenic bacteria.Archives of microbiology · 2026Review
- Antagonistic Interactions BetweenInternational journal of molecular sciences · 2025Article
- Gene expression analyses on Dickeya solani strains of diverse virulence levels unveil important pathogenicity factors for this species.Scientific reports · 2025Article
- SydR, a redox-sensing MarR-type regulator ofmBio · 2024Article
- Structural basis of transcriptional regulation by UrtR in response to uric acid.Nucleic acids research · 2024Article
- Regulation of bacterial virulence genes by PecS family transcription factors.Journal of bacteriology · 2024Review
- MarR Family Transcriptional Regulators and Their Roles in Plant-Interacting Bacteria.Microorganisms · 2023Review
- Transcription Factor PecS MediatesJournal of bacteriology · 2023Article
- The integration host factor regulates multiple virulence pathways in bacterial pathogen Dickeya zeae MS2.Molecular plant pathology · 2022Article
- Mapping the Complex Transcriptional Landscape of the Phytopathogenic Bacterium Dickeya dadantii.mBio · 2022Article
- Genomic Comparisons and Phenotypic Diversity ofFrontiers in plant science · 2022Article
- Identification of new Dickeya dadantii virulence factors secreted by the type 2 secretion system.PloS one · 2022Article
- Dickeya Manipulates Multiple Quorum Sensing Systems to Control Virulence and Collective Behaviors.Frontiers in plant science · 2022Review
- The nucleoid-associated protein IHF acts as a 'transcriptional domainin' protein coordinating the bacterial virulence traits with global transcription.Nucleic acids research · 2021Article
- Review
- RNA Chaperones Hfq and ProQ Play a Key Role in the Virulence of the Plant Pathogenic BacteriumFrontiers in microbiology · 2021Article
- Innovation and Application of the Type III Secretion System Inhibitors in Plant Pathogenic Bacteria.Microorganisms · 2020Review
- Multistep Metabolic Engineering of Bacillus licheniformis To Improve Pulcherriminic Acid Production.Applied and environmental microbiology · 2020Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenicity of the enterobacterium Erwinia chrysanthemi (Dickeya dadantii), the causative agent of soft-rot disease in many plants, is a complex process involving several factors whose production is subject to temporal regulation during infection. PecS is a transcriptional regulator that controls production of various virulence factors. Here, we used microarray analysis to define the PecS regulon and demonstrated that PecS notably regulates a wide range of genes that could be linked to pathogenicity and to a group of genes concerned with evading host defenses. Among the targets are the genes encoding plant cell wall-degrading enzymes and secretion systems and the genes involved in flagellar biosynthesis, biosurfactant production, and the oxidative stress response, as well as genes encoding toxin-like factors such as NipE and hemolysin-coregulated proteins. In vitro experiments demonstrated that PecS interacts with the regulatory regions of five new targets: an oxidative stress response gene (ahpC), a biosurfactant synthesis gene (rhlA), and genes encoding exported proteins related to other plant-associated bacterial proteins (nipE, virK, and avrL). The pecS mutant provokes symptoms more rapidly and with more efficiency than the wild-type strain, indicating that PecS plays a critical role in the switch from the asymptomatic phase to the symptomatic phase. Based on this, we propose that the temporal regulation of the different groups of genes required for the asymptomatic phase and the symptomatic phase is, in part, the result of a gradual modulation of PecS activity triggered during infection in response to changes in environmental conditions emerging from the interaction between both partners.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.