ArticleLife sciences2008
Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition.
Article in Life sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function.Basic & clinical pharmacology & toxicology · 2025Pooled it
- Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide.British journal of clinical pharmacology · 2010Trial
- Exercise Enhances Anti-contractile Effects of PVAT Through Endogenous HCardiovascular drugs and therapy · 2025Article
- Homocysteine Attack on Vascular Endothelium-Old and New Features.International journal of molecular sciences · 2025Review
- The therapeutic potential of hydrogen sulfide and its donors, a new discovery in vascular diseases.Journal of cardiovascular pharmacology · 2025Article
- Role of Gut Microbial Metabolites in Cardiovascular Diseases-Current Insights and the Road Ahead.International journal of molecular sciences · 2024Review
- Role of hydrogen sulfide in health and disease.MedComm · 2024Review
- Hydrogen sulfide and its role in female reproduction.Frontiers in veterinary science · 2024Review
- Hydrogen sulfide-induced post-translational modification as a potential drug target.Genes & diseases · 2023Review
- Comparative Study of Different HAntioxidants (Basel, Switzerland) · 2023Article
- The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter.The FEBS journal · 2022Review
- Hydrogen sulfide: A new therapeutic target in vascular diseases.Frontiers in endocrinology · 2022Review
- Review
- Distinct Pharmacological Properties of Gaseous CO and CO-Releasing Molecule in Human Platelets.International journal of molecular sciences · 2021Article
- The Cardiovascular Effects of Hydrogen Sulfide: The Epigenetic Mechanisms.Advances in experimental medicine and biology · 2021Article
- Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology.Advances in experimental medicine and biology · 2021Review
- The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone.Biomolecules · 2020Review
- S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease.Antioxidants & redox signaling · 2020Review
- Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Vasorelaxation elicited by endogenous and exogenous hydrogen sulfide in mouse mesenteric arteries.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
aimsHydrogen sulfide (H(2)S) at low concentrations serves as a physiological endogenous vasodilator molecule, while at higher concentrations it can trigger cytotoxic effects. The aim of our study was to elucidate the potential mechanisms responsible for the effects of H(2)S on vascular tone. MAIN
methodsWe measured the vascular tone in vitro in precontracted rat thoracic aortic rings and we have tested the effect of different oxygen levels and a variety of inhibitors affecting known vasodilatory pathways. We have also compared the vascular effect of high concentrations of H(2)S to those of pharmacological inhibitors of oxidative phosphorylation. Furthermore, we measured adenosine triphosphate (ATP)-levels in the same vascular tissues. KEY
findingsWe have found that in rat aortic rings: (1) H(2)S decreases ATP levels; (2) relaxations to H(2)S depend on the ambient oxygen concentration; (3) prostaglandins do not take part in the H(2)S induced relaxations; (4) the 3':5'-cyclic guanosine monophosphate (cGMP)-nitric oxide (NO) pathway does not have a role in the relaxations (5) the role of K(ATP) channels is limited, while Cl(-)/HCO(3)(-) channels have a role in the relaxations. (6): We have observed that high concentrations of H(2)S relax the aortic rings in a fashion similar to sodium cyanide, and both agents reduce cellular ATP levels to a comparable degree. SIGNIFICANCE: H(2)S, a new gasotransmitter of emerging importance, leads to relaxation via Cl(-)/HCO(3)(-) channels and metabolic inhibition and the interactions of these two factors depend on the oxygen levels of the tissue.
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Registered trials
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