ReviewTrends in pharmacological sciences2008
Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins.
Review in Trends in pharmacological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Permeation mechanisms through the selectivity filter and the open helix bundle crossing gate of GIRK2.Computational and structural biotechnology journal · 2020Article
- G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury.Journal of pain research · 2020Article
- Mechanisms of cannabinoid CBEBioMedicine · 2019Article
- Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2019Article
- Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.ACS chemical neuroscience · 2019Article
- Regulator of G-Protein Signaling 4 (RGS4) Controls Morphine Reward by Glutamate Receptor Activation in the Nucleus Accumbens of Mouse Brain.Molecules and cells · 2018Article
- Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures.Frontiers in psychiatry · 2018Article
- A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- mGlu1 receptor as a drug target for treatment of substance use disorders: time to gather stones together?Psychopharmacology · 2017Review
- Article
- Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels.The Journal of physiology · 2014Article
- GIRK channel modulation by assembly with allosterically regulated RGS proteins.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia.The Journal of pharmacology and experimental therapeutics · 2012Article
- Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance.Alcoholism, clinical and experimental research · 2012Article
- The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum.Science signaling · 2012Article
- Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system.Reviews in the neurosciences · 2012Review
- Hooked on benzodiazepines: GABAA receptor subtypes and addiction.Trends in neurosciences · 2011Review
- Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.PloS one · 2011Article
- Bi-directional effect of increasing doses of baclofen on reinforcement learning.Frontiers in behavioral neuroscience · 2011Article
- Activators of G-protein signaling 3: a drug addiction molecular gateway.Behavioural pharmacology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Regulator of G-protein signaling (RGS) proteins are strong modulators of G-protein-mediated pathways in the nervous system. One function of RGS proteins is to accelerate the activation-deactivation kinetics of G-protein-coupled inwardly rectifying potassium (GIRK) channels. The opening of GIRK channels reduces the firing rates of neurons. Recent studies indicate that RGS proteins also modulate the coupling efficiency between gamma-aminobutyric acid type B (GABA(B)) receptors and GIRK channels in dopamine neurons of the ventral tegmental area (VTA), the initial target for addictive drugs in the brain reward pathway. Chronic drug exposure can dynamically regulate the expression levels of RGS. Functional and behavioral studies now reveal that levels of RGS2 protein, through selective association with GIRK3, critically determine whether GABA(B) agonists are excitatory or inhibitory in the VTA. The regulation of RGS protein in the reward pathway might underlie adaptation to different types of addictive drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.