ReviewBrain research2008
Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models.
Review in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of D-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: a randomized controlled trial.Psychopharmacology · 2011Trial
- Regression of Liver Steatosis Following Phosphatidylcholine Administration: A Review of Molecular and Metabolic Pathways Involved.Frontiers in pharmacology · 2022Review
- Maternal betaine supplementation during gestation modifies hippocampal expression of GR and its regulatory miRNAs in neonatal piglets.The Journal of veterinary medical science · 2016Article
- Epigenetics and nutritional environmental signals.Integrative and comparative biology · 2014Review
- Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.Cancer letters · 2014Review
- One-carbon metabolism factors and leukocyte telomere length.The American journal of clinical nutrition · 2013Article
- Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research.JPEN. Journal of parenteral and enteral nutrition · 2013Article
- Detection of metabolic syndrome in schizophrenia and implications for antipsychotic therapy : is there a role for folate?Molecular diagnosis & therapy · 2013Review
- One-carbon metabolism factors and endometrial cancer risk.British journal of cancer · 2013Article
- Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats.Brain research · 2012Article
- Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects.The Proceedings of the Nutrition Society · 2012Review
- A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.Cell · 2011Article
- The effects of dietary choline.Neuroscience bulletin · 2011Review
- Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.Gastroenterology · 2011Article
- Nutritional genomics: defining the dietary requirement and effects of choline.The Journal of nutrition · 2011Review
- Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner.Alcoholism, clinical and experimental research · 2011Article
- Early life programming and neurodevelopmental disorders.Biological psychiatry · 2010Review
- DNA hypomethylation in the origin and pathogenesis of human diseases.Cellular and molecular life sciences : CMLS · 2009Review
- Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain.The Journal of biological chemistry · 2009Article
- Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Choline is an essential nutrient that is critical during fetal brain development. Choline deficiency, through disturbing methyl metabolism, may alter DNA methylation and thereby influence neural precursor cell proliferation and apoptosis. This results in long term alterations in brain structure and function, specifically memory function. A recommended dietary intake for choline in humans was set in 1998, and a portion of the choline requirement can be met via endogenous de novo synthesis of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) in the liver. Though many foods contain choline, many humans do not get enough in their diets. When deprived of dietary choline, most adult men and postmenopausal women developed signs of organ dysfunction (fatty liver, liver or muscle cell damage). However, only a portion of premenopausal women developed such problems. The difference in requirement occurs because estrogen induces expression of the PEMT gene and allows premenopausal women to make more of their needed choline endogenously. In addition, there is significant variation in the dietary requirement for choline that can be explained by common genetic variants (single nucleotide polymorphisms; SNPs) in genes of choline and folate metabolism. Some of these increase the risk of choline deficiency many-fold. These variations in choline requirement could have important implications for brain development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.