ArticleAmerican journal of surgery2008
Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury.
Article in American journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research.Frontiers in physiology · 2020Pooled it
- Prediction of Multiple Organ Failure Complicated by Moderately Severe or Severe Acute Pancreatitis Based on Machine Learning: A Multicenter Cohort Study.Mediators of inflammation · 2021Article
- SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes.Diabetes · 2017Article
- Beta Cell Regeneration in Adult Mice: Controversy Over the Involvement of Stem Cells.Current stem cell research & therapy · 2016Review
- Keratoacanthoma Pathobiology in Mouse Models.Diseases (Basel, Switzerland) · 2014Article
- The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice.PloS one · 2013Article
- Manganese superoxide dismutase is dispensable for post-natal development and lactation in the murine mammary gland.Free radical research · 2012Article
- Enrichment of murine CD68+ CCR2+ and CD68+ CD206+ lung macrophages in acute pancreatitis-associated acute lung injury.PloS one · 2012Article
- Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- Article
- Nuclear factor kappa B-dependent gene transcription in cholecystokinin- and tumor necrosis factor-alpha-stimulated isolated acinar cells is regulated by p38 mitogen-activated protein kinase.American journal of surgery · 2010Article
- A novel model of severe gallstone pancreatitis: murine pancreatic duct ligation results in systemic inflammation and substantial mortality.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAcute lung injury is a major determinant of outcomes in acute pancreatitis. We evaluated acute lung injury and stress kinase activation in ligation-induced acute pancreatitis in mice.
methodsMice with duct ligation or sham operation were killed after 24 or 48 hours.
resultsIn addition to acute pancreatitis, duct ligation was associated with pulmonary morphologic changes indicative of acute lung injury (alveolar septal thickening, congestion, and neutrophil infiltration). Furthermore, immunoblotting showed stress kinase activation in the pancreas and lung after ligation. Although mortality was observed in the ligated group, that is consistent with severe lung injury, it requires further evaluation.
conclusionsBile and pancreatic duct ligation in the mouse is associated with pancreatic and pulmonary stress kinase activation and acute inflammatory changes consistent with early acute pancreatitis and acute lung injury. Our findings are important as acute lung injury increases mortality in clinical acute pancreatitis and stress kinases are established proinflammatory signal transducers.
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Registered trials
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