ReviewBiochimica et biophysica acta2009
Small RNA-directed heterochromatin formation in the context of development: what flies might learn from fission yeast.
Review in Biochimica et biophysica acta, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Structural basis of endo-siRNA processing by Drosophila Dicer-2 and Loqs-PD.Nucleic acids research · 2025Article
- In Response to Abiotic Stress, DNA Methylation Confers EpiGenetic Changes in Plants.Plants (Basel, Switzerland) · 2021Review
- Centromere and Pericentromere Transcription: Roles and Regulation … in Sickness and in Health.Frontiers in genetics · 2018Review
- Antisense Transcription of Retrotransposons in Drosophila: An Origin of Endogenous Small Interfering RNA Precursors.Genetics · 2016Article
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
- Recurrent and recent selective sweeps in the piRNA pathway.Evolution; international journal of organic evolution · 2013Article
- The piRNA pathway in flies: highlights and future directions.Current opinion in genetics & development · 2013Review
- RNA editing regulates transposon-mediated heterochromatic gene silencing.Nature communications · 2013Article
- Mapping the pericentric heterochromatin by comparative genomic hybridization analysis and chromosome deletions in Drosophila melanogaster.Genome research · 2012Article
- Production of artificial piRNAs in flies and mice.RNA (New York, N.Y.) · 2012Article
- Phylogenomic analysis reveals dynamic evolutionary history of the Drosophila heterochromatin protein 1 (HP1) gene family.PLoS genetics · 2012Article
- RNA and epigenetic silencing: insight from fission yeast.Development, growth & differentiation · 2012Review
- RNA interference and heterochromatin assembly.Cold Spring Harbor perspectives in biology · 2011Review
- An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer.The EMBO journal · 2011Article
- Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism.Advances in experimental medicine and biology · 2011Review
- Minireview: Switching on progesterone receptor expression with duplex RNA.Molecular endocrinology (Baltimore, Md.) · 2010Review
- The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A link between the RNAi system and heterochromatin formation has been established in several model organisms including Schizosaccharomyces pombe and Arabidopsis thaliana. However, the data to support a role for small RNAs and the associated machinery in transcriptional gene silencing in animal systems is more tenuous. Using the S. pombe system as a model, we analyze the role of small RNA pathway components and associated small RNAs in regulating transposable elements and potentially directing heterochromatin formation at these elements in Drosophila melanogaster.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.