ReviewNeuroscience and biobehavioral reviews2009
Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder.
Review in Neuroscience and biobehavioral reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct.Psychopharmacology · 2024Pooled it
- Effects of exercise and psychological interventions on smartphone addiction among university students: A systematic review.Frontiers in psychology · 2022Pooled it
- Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: a meta-analytic review.Clinical psychology review · 2011Pooled it
- Go/No Go task performance predicts cortical thickness in the caudal inferior frontal gyrus in young adults with and without ADHD.Brain imaging and behavior · 2016Trial
- A comparison of three types of web-based inhibition training for the reduction of alcohol consumption in problem drinkers: study protocol.BMC public health · 2014Trial
- When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting.PloS one · 2012Trial
- Associations between childhood risk factors and alcohol treatment outcomes in adolescence.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Article
- The role of impulsivity in injection-related risk behaviours among people who inject drugs in Montreal, Canada.Harm reduction journal · 2025Article
- Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake.Alcohol (Fayetteville, N.Y.) · 2025Review
- Genetic pathways regulating the longitudinal acquisition of cocaine self-administration in a panel of inbred and recombinant inbred mice.Cell reports · 2023Article
- Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice.Nature communications · 2023Article
- Alpha and Theta Oscillations Are Causally Linked to Interference Inhibition: Evidence from High-Definition Transcranial Alternating Current Stimulation.Brain sciences · 2023Article
- The NIMH intramural healthy volunteer dataset: A comprehensive MEG, MRI, and behavioral resource.Scientific data · 2022Article
- Increased resting-state alpha coherence and impaired inhibition control in young smokers.Frontiers in neuroscience · 2022Article
- Effectiveness of Response Inhibition Training and Its Long-Term Effects in Healthy Adults: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2022Review
- Cigarette-specific disgust aroused by smoking warning images strengthens smokers' inhibitory control under smoking-related background in Go/NoGo task.Psychopharmacology · 2021Article
- Article
- Unique features of stimulus-based probabilistic reversal learning.Behavioral neuroscience · 2021Article
- Brain micro-architecture and disinhibition: a latent phenotyping study across 33 impulsive and compulsive behaviours.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task.Genes, brain, and behavior · 2021Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The co-morbidity between attention deficit hyperactivity disorder (ADHD) and substance abuse and dependence disorders may have multiple causes and consequences. In this review, we will describe neurobehavioral, genetic and animal model studies that support the notion that a common, genetically determined failure of response inhibition function is an endophenotype for both disorders. Through an impairment in the ability to cognitively control pre-potent behaviors, subjects can exhibit a collection of ADHD-like traits (impulsivity and hyperactivity), as well as susceptibility for the initiation of drug taking and its ultimate progression to an inflexible, uncontrollable form. At the neural level, dysfunction within circuitry that includes the ventrolateral frontal and cingulate cortices, as well as in associated basal ganglia zones, contributes to a common pattern of behavioral impairment, explaining aspects of co-morbidity. Animal models of substance abuse/dependence and ADHD that exhibit deficits in response inhibition have substantiated the role of this endophenotype in both disorders and their co-morbidity and should provide a testing ground for interventions targeting it. New directions for research that will further explore this hypothesis and begin to reveal the underlying biological mechanisms will be proposed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.