Trial reportLung
Effect of tiotropium on cough reflex sensitivity in acute viral cough.
Trial report in Lung. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Inhaled anti-cholinergics for prolonged non-specific cough in children.The Cochrane database of systematic reviews · 2004Pooled it
- Budesonide/glycopyrronium/formoterol fumarate co-suspension metered dose inhaler relieves cough after lobectomy: a randomized controlled study.Translational lung cancer research · 2025Article
- Staphylococcus aureus enterotoxin sensitization is associated with declined capsaicin cough sensitivity in chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Article
- Decreased capsaicin cough reflex sensitivity predicts hospitalisation due to COPD.BMJ open respiratory research · 2023Article
- COVID-19, Suffering and Palliative Care: A Review.The American journal of hospice & palliative care · 2022Review
- Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses.The Lancet. Respiratory medicine · 2021Review
- The evidence on tiotropium bromide in asthma: from the rationale to the bedside.Multidisciplinary respiratory medicine · 2017Review
- TRP functions in the broncho-pulmonary system.Seminars in immunopathology · 2016Review
- How does rhinovirus cause the common cold cough?BMJ open respiratory research · 2016Article
- Effect of viral upper respiratory tract infection on cough reflex sensitivity.Journal of thoracic disease · 2014Review
- Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease.The Korean journal of internal medicine · 2014Article
- Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?The Journal of allergy and clinical immunology · 2014Article
- Antitussive drugs--past, present, and future.Pharmacological reviews · 2014Review
- Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: a national cross-sectional cohort study.BMC pulmonary medicine · 2013Article
- The role of bronchodilator treatment in the prevention of exacerbations of COPD.The European respiratory journal · 2012Review
- Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicin.Cough (London, England) · 2012Article
- Cough: an unmet clinical need.British journal of pharmacology · 2011Review
- Pharmacologic management of cough.Otolaryngologic clinics of North America · 2010Review
- Acute cough: a diagnostic and therapeutic challenge.Cough (London, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesCough is the most common complaint for which patients in the United States seek medical attention. Few, if any, effective therapies exist for the most common form of acute cough, that due to viral upper respiratory tract infection (URI). The aim of this study was to evaluate the effect of the anticholinergic agent tiotropium bromide on cough reflex sensitivity in subjects with acute viral URI. PATIENTS: Otherwise healthy adult nonsmokers with acute viral URI were randomized to receive inhaled tiotropium, 18 microg once daily, or matched placebo, for 7 days. A control group of healthy volunteers underwent an identical protocol. MEASUREMENTS AND
resultsCough reflex sensitivity to inhaled capsaicin was measured at baseline (Day 0), and 1 h after the first (Day 1) and seventh (Day 7) dose of tiotropium or placebo. Concentrations of capsaicin inducing two or more (C (2)) and five or more coughs (C (5)) were determined. In subjects with URI, tiotropium (n = 11) demonstrated inhibition of cough reflex sensitivity relative to baseline (increased log C (2) [p = 0.004] and log C (5) [p = 0.0004]) after the first dose. No change occurred in the placebo group (n = 10). After 7 days, mean log C (2) was significantly increased in the tiotropium group relative to placebo (p = 0.03). Although FEF(25-75) was also increased in the tiotropium group (p = 0.016), there was no significant correlation between changes in cough reflex sensitivity and FEF(25-75). Tiotropium had no effect in healthy volunteers (n = 24).
conclusionsTiotropium inhibits cough reflex sensitivity to capsaicin in subjects with acute viral URI. The antitussive effect of tiotropium may occur through a mechanism other than bronchodilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.