ReviewMammalian genome : official journal of the International Mammalian Genome Society2008
Functional genetic variation of human miRNAs and phenotypic consequences.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed.
- Disease-related miRNA mutations are associated with mature miRNA secondary structure changes.Biophysical journal · 2025Article
- Review
- Polymorphisms in KSHV-encoded microRNA sequences affect levels of mature viral microRNA in Kaposi Sarcoma lesions.Oncotarget · 2018Article
- Atlas of tissue- and developmental stage specific gene expression for the bovine insulin-like growth factor (IGF) system.PloS one · 2018Article
- Clustering Pattern and Functional Effect of SNPs in Human miRNA Seed Regions.International journal of genomics · 2018Article
- Association of the PLCB1 gene with drug dependence.Scientific reports · 2017Article
- Identification and functional characterization of microRNAs reveal a potential role in gastric cancer progression.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
- miRNA-183 suppresses apoptosis and promotes proliferation in esophageal cancer by targeting PDCD4.Molecules and cells · 2014Article
- miRNome in myocardial infarction: Future directions and perspective.World journal of cardiology · 2014Review
- MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.Scandinavian journal of clinical and laboratory investigation · 2014Article
- Circular RNAs are depleted of polymorphisms at microRNA binding sites.Bioinformatics (Oxford, England) · 2014Article
- Identification of novel sequence variations in microRNAs in chronic lymphocytic leukemia.Carcinogenesis · 2014Article
- Article
- Article
- Insights on the functional interactions between miRNAs and copy number variations in the aging brain.Frontiers in molecular neuroscience · 2013Review
- Long QT syndrome: beyond the causal mutation.The Journal of physiology · 2013Review
- Prioritization of genetic variants in the microRNA regulome as functional candidates in genome-wide association studies.Human mutation · 2013Article
- Emerging roles for miRNAs in the development, diagnosis, and treatment of diabetic nephropathy.Current diabetes reports · 2013Review
- Needles in the genetic haystack of lipid disorders: single nucleotide polymorphisms in the microRNA regulome.Journal of lipid research · 2013Review
- A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance.BMC genetics · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large number of human protein-coding genes are finely regulated by one or more microRNAs. Members of this small noncoding RNA family have emerged as important post-transcriptional regulators of gene expression and are involved in a number of disease phenotypes. Variability in the human genome is extensive and includes the common and rare single nucleotide polymorphisms (SNPs) and copy number variations (CNVs). The functional significance of the genome's variability is under intense investigation. In this article we review the emerging literature on how human genomic variation influences the outcome of microRNA targeting and the associated phenotypic effects. Illustrative examples are discussed that demonstrate the biological importance of functional polymorphisms affecting miRNA-mediated gene regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.