ReviewJournal of neurology2008
Genes associated with Parkinson syndrome.
Review in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 90 citations in OpenAlex.
- Cyclic nucleotide phosphodiesterases as drug targets.Pharmacological reviews · 2025Review
- Revolutionizing our understanding of Parkinson's disease: Dr. Heinz Reichmann's pioneering research and future research direction.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Capturing the catalytic intermediates of parkin ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multimodal neuroimaging and behavioral assessment of α-synuclein polymorphism rs356219 in older adults.Neurobiology of aging · 2018Article
- Motor and non-motor features of Parkinson's disease in LRRK2 G2019S carriers versus matched controls.Journal of the neurological sciences · 2018Article
- Cysteines as Redox Molecular Switches and Targets of Disease.Frontiers in molecular neuroscience · 2017Review
- Resveratrol Modulation of Protein Expression inOxidative medicine and cellular longevity · 2017Article
- Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease.Protein & cell · 2016Article
- Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders.International journal of molecular sciences · 2015Review
- α-Synuclein Misfolding Versus Aggregation Relevance to Parkinson's Disease: Critical Assessment and Modeling.Molecular neurobiology · 2015Review
- Ubiquitin-Proteasome System in Neurodegenerative Disorders.Journal of drug metabolism & toxicology · 2015Article
- A random set scoring model for prioritization of disease candidate genes using protein complexes and data-mining of GeneRIF, OMIM and PubMed records.BMC bioinformatics · 2014Article
- Regulation of autophagy by LRRK2 in Caenorhabditis elegans.Neuro-degenerative diseases · 2014Article
- Time trends in incidence of Parkinson's disease diagnosis in UK primary care.Journal of neurology · 2013Article
- Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease.Neurobiology of disease · 2013Review
- Article
- LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.PloS one · 2013Article
- Article
- Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation.Molecular neurodegeneration · 2011Article
- Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2).The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic findings have changed our views on Parkinson's disease (PD) and parkinsonism, which will be collectively referred to as Parkinsonian Syndrome (PS) in the present manuscript. Mutations in several genes are found to cause monogenic forms of the disorder. Point mutations, duplications and triplications in the alpha-synuclein gene cause a rare dominant form of PS in families. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as a much more common cause for dominant PS, especially in certain ethnic groups, while mutations in the parkin gene, in DJ-1, PINK1 and ATP13A2 cause autosomal recessive parkinsonism of early onset. The monogenic variants are important tools in identifying cellular pathways that also shed light on the molecular pathogenesis of sporadic PS and some of these genes may play a role in the etiology of the common sporadic form of PS. Here we add recent findings to a greatly challenging puzzle.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.