ReviewJournal of cancer research and clinical oncology2009
Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors.
Review in Journal of cancer research and clinical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- The Evolving Landscape of the Molecular Epidemiology of Malignant Pleural Mesothelioma.Journal of clinical medicine · 2021Review
- Review
- The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma.Radiology and oncology · 2019Article
- Biomarkers for Early Diagnosis and Prognosis of Malignant Pleural Mesothelioma: The Quest Goes on.Cancers · 2018Article
- Review
- Software for Apportionment of Asbestos-Related Mesotheliomas.Canadian respiratory journal · 2016Review
- Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing.PloS one · 2015Article
- The assessment of the malignant mesothelioma cases and environmental asbestos exposure in Sivas province, Turkey.Environmental geochemistry and health · 2014Article
- Analyses of radiation and mesothelioma in the US Transuranium and Uranium Registries.American journal of public health · 2013Article
- NLRP1 polymorphisms in patients with asbestos-associated mesothelioma.Infectious agents and cancer · 2012Article
- Polycomb repressor complex-2 is a novel target for mesothelioma therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice.Cancer chemotherapy and pharmacology · 2011Article
- Non-neoplastic and neoplastic pleural endpoints following fiber exposure.Journal of toxicology and environmental health. Part B, Critical reviews · 2011Review
- Merkel cell polyomavirus is not detected in mesotheliomas.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010Article
- The investigation of effects of quercetin and its combination with Cisplatin on malignant mesothelioma cells in vitro.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalignant pleural mesothelioma (MPM) is a rare and aggressive tumor for which no effective therapy exists despite the discovery of many possible molecular and genetic targets. The late stage of MPM diagnosis and the long latency that exist between some exposures and diagnosis have made it difficult to comprehensively evaluate the role of risk factors and their downstream molecular effects.
methodsThis manuscript is a review of current literature about the pathogenesis of malignant mesothelioma. In this overview, current published studies concerning pathogenesis of malignant mesothelioma are reviewed, with insights into its etiology and pathogenesis. We searched pubmed using the following subjects: mesothelioma, radiation, genetics, pediatric malignant mesothelioma, SV40 virus, and growth factors. We selected 350 valuable articles of which 152 sources were used to complete this review.
conclusionMany risk factors for MPM development have been recognized including environmental exposures, genetic susceptibility, viral contamination, and radiation. In this review, we discuss the current molecular and genetic contributors to MPM pathogenesis and the risk factors associated with these carcinogenic processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.