ArticleJournal of neuro-oncology2009
In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma.
Article in Journal of neuro-oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Extracellular Vesicle-Mediated Nucleolin Transfer in Glioblastoma: A Targetable Axis Driving Blood-Tumour Barrier Formation.Journal of extracellular vesicles · 2026Article
- A clinically relevant computed tomography (CT) radiomics strategy for intracranial rodent brain tumour monitoring.Scientific reports · 2024Article
- [Theranostics · 2024Article
- Article
- Made to Measure: Patient-Tailored Treatment of Multiple Sclerosis Using Cell-Based Therapies.International journal of molecular sciences · 2021Review
- The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma.Journal of personalized medicine · 2021Review
- Review
- A Real-Time Non-invasive Auto-bioluminescent Urinary Bladder Cancer Xenograft Model.Molecular imaging and biology · 2017Article
- Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.Cancer cell · 2016Article
- Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.Stem cell research & therapy · 2015Article
- Hyperbaric oxygen promotes malignant glioma cell growth and inhibits cell apoptosis.Oncology letters · 2015Article
- Identification of imaging biomarkers for the assessment of tumour response to different treatments in a preclinical glioma model.European journal of nuclear medicine and molecular imaging · 2015Article
- Intra-adrenal murine TH-MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents.Cancer immunology, immunotherapy : CII · 2015Article
- Macrophage Ablation Reduces M2-Like Populations and Jeopardizes Tumor Growth in a MAFIA-Based Glioma Model.Neoplasia (New York, N.Y.) · 2015Article
- Brain Tumor Immunotherapy: What have We Learned so Far?Frontiers in oncology · 2015Review
- The dark side of ID8-Luc2: pitfalls for luciferase tagged murine models for ovarian cancer.Journal for immunotherapy of cancer · 2015Article
- Validation of an engineered cell model for in vitro and in vivo HIF-1α evaluation by different imaging modalities.Molecular imaging and biology · 2014Article
- Mouse glioma immunotherapy mediated by A2B5+ GL261 cell lysate-pulsed dendritic cells.Journal of neuro-oncology · 2014Article
- Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.Clinical & developmental immunology · 2013Article
- Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model.Cancer immunology, immunotherapy : CII · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The value of bioluminescence imaging (BLI) for experimental cancer models has become firmly established. We applied BLI to the GL261 glioma model in the context of dendritic cell (DC) immunotherapy. Initial validation revealed robust linear correlations between in vivo, ex vivo and in vitro luciferase activity measurements. Ex vivo BLI demonstrated midline crossing and leakage of tumor cells. Orthotopically challenged mice followed with BLI showed an initial adaptation phase, after which imaging data correlated linearly with stereologically determined tumor dimensions. Transition from healthy to moribund state corresponded with an increasing in vivo flux but the onset of neurological deficit was clearly delayed compared to the onset of in vivo flux increase. BLI was implemented in prophylactic immunotherapy and imaging data were prognostic for therapy outcome. Three distinct response patterns were detected. Our data underscore the feasibility of in vivo BLI in an experimental immunotherapeutic setting in the GL261 glioma model.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.