ArticlePLoS pathogens2008
Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release.Scientific reports · 2016Trial
- Revisiting the streptococcal M protein: modern perspectives on antibody function, host interactions, and therapeutic targeting.Frontiers in immunology · 2026Review
- Article
- Distinct Serotypes of Streptococcal M Proteins Mediate Fibrinogen-Dependent Platelet Activation and Proinflammatory Effects.Infection and immunity · 2022Article
- Effects of TolC on the pathogenicity of porcine extraintestinal pathogenicFrontiers in immunology · 2022Article
- Group AFrontiers in cardiovascular medicine · 2021Article
- Observational
- HP1717 Contributes to Streptococcus suis Virulence by Inducing an Excessive Inflammatory Response and Influencing the Biosynthesis of the Capsule.Microorganisms · 2019Article
- NEWS2 is Superior to qSOFA in Detecting Sepsis with Organ Dysfunction in the Emergency Department.Journal of clinical medicine · 2019Article
- Fisetin LowersFrontiers in microbiology · 2018Article
- HP1330 Contributes toFrontiers in immunology · 2017Article
- Platelet-Dependent Neutrophil Function Is Dysregulated by M Protein from Streptococcus pyogenes.Infection and immunity · 2015Article
- Host responses to group a streptococcus: cell death and inflammation.PLoS pathogens · 2014Review
- Antibody orientation at bacterial surfaces is related to invasive infection.The Journal of experimental medicine · 2012Article
- Loss of outer membrane protein C in Escherichia coli contributes to both antibiotic resistance and escaping antibody-dependent bactericidal activity.Infection and immunity · 2012Article
- Clinical and molecular characteristics of invasive and noninvasive skin and soft tissue infections caused by group A Streptococcus.Journal of clinical microbiology · 2011Article
- Article
- The nonideal coiled coil of M protein and its multifarious functions in pathogenesis.Advances in experimental medicine and biology · 2011Review
- The response of the host microcirculation to bacterial sepsis: does the pathogen matter?Journal of molecular medicine (Berlin, Germany) · 2010Review
- Streptococcus adherence and colonization.Microbiology and molecular biology reviews : MMBR · 2009Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcal toxic shock syndrome (STSS) caused by Streptococcus pyogenes is a clinical condition with a high mortality rate despite modern intensive care. A key feature of STSS is excessive plasma leakage leading to hypovolemic hypotension, disturbed microcirculation and multiorgan failure. Previous work has identified a virulence mechanism in STSS where M1 protein of S. pyogenes forms complexes with fibrinogen that activate neutrophils to release heparin-binding protein (HBP), an inducer of vascular leakage. Here, we report a marked inter-individual difference in the response to M1 protein-induced HBP release, a difference found to be related to IgG antibodies directed against the central region of the M1 protein. To elicit massive HBP release, such antibodies need to be part of the M1 protein-fibrinogen complexes. The data add a novel aspect to bacterial pathogenesis where antibodies contribute to the severity of disease by promoting a pathologic inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.