ArticleArteriosclerosis, thrombosis, and vascular biology2008
FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 33 citations in OpenAlex.
- Focal adhesion proteins confer smooth muscle anoikis resistance and protection against aortic aneurysm and dissection.JCI insight · 2026Article
- HINT1 aggravates aortic aneurysm by targeting ITGA6/FAK axis in vascular smooth muscle cells.The Journal of clinical investigation · 2025Article
- FAK Family Kinases: A Potential Therapeutic Target for Atherosclerosis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression.Cell death & disease · 2023Article
- Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysisWorld journal of gastroenterology · 2022Article
- FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes.Circulation research · 2021Article
- FAK Family Kinases in Vascular Diseases.International journal of molecular sciences · 2020Review
- Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-Mediated Cyclin D1 Transcription.Circulation research · 2019Article
- Transgelin as a potential target in the reversibility of pulmonary arterial hypertension secondary to congenital heart disease.Journal of cellular and molecular medicine · 2018Article
- Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor.Biochemistry · 2017Article
- Inhibition of Diaphanous Formin Signaling In Vivo Impairs Cardiovascular Development and Alters Smooth Muscle Cell Phenotype.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes.The Journal of biological chemistry · 2015Article
- Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta.The Journal of clinical investigation · 2013Article
- FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.The American journal of pathology · 2013Article
- The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.Nature communications · 2013Article
- Targeted focal adhesion kinase activation in cardiomyocytes protects the heart from ischemia/reperfusion injury.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Signaling mechanisms that regulate smooth muscle cell differentiation.Arteriosclerosis, thrombosis, and vascular biology · 2011Review
- FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveSmooth muscle cell (SMC) differentiation is a dynamic process that must be tightly regulated for proper vascular development and to control the onset of vascular disease. Our laboratory previously reported that a specific focal adhesion kinase (FAK) inhibitor termed FRNK (FAK Related Non-Kinase) is selectively expressed in large arterioles when SMCs are transitioning from a synthetic to contractile phenotype and that FRNK inhibits FAK-dependent SMC proliferation and migration. Herein, we sought to determine whether FRNK expression modulates SMC phenotypes in vivo. METHODS AND
resultsWe present evidence that FRNK(-/-) mice exhibit attenuated SM marker gene expression during postnatal vessel growth and after vascular injury. We also show that FRNK expression is regulated by transforming growth factor (TGF)-beta and that forced expression of FRNK in cultured cells induces serum- and TGF-beta-stimulated SM marker gene expression, whereas FRNK deletion or expression of a constitutively activated FAK variant attenuated SM gene transcription.
conclusionsThese data highlight the possibility that extrinsic signals regulate the SMC gene profile, at least in part, by modulating the expression of FRNK and that tight regulation of FAK activity by FRNK is important for proper SMC differentiation during development and after vascular injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.