ArticleAmerican journal of respiratory cell and molecular biology2009
Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.
Article in American journal of respiratory cell and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- The study of immunological markers in tuberculosis across animal models and its translation to human research.Lab animal · 2026Review
- Adaptive immunity shapes baseline physiology ofbioRxiv : the preprint server for biology · 2026Article
- Repeated pulmonary dosing of β-glucan-chitosan-PLGA nanoparticles controlsAntimicrobial agents and chemotherapy · 2026Article
- Mycobacterium tuberculosis infection drives a type I IFN signature in lung lymphocytes.Cell reports · 2022Article
- Blood RNA signatures predict recent tuberculosis exposure in mice, macaques and humans.Scientific reports · 2020Article
- Impact of the Polymorphism of theIranian journal of medical sciences · 2019Article
- Review
- Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2016Article
- Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization.Scientific reports · 2016Article
- Whole genome response in guinea pigs infected with the high virulence strain Mycobacterium tuberculosis TT372.Tuberculosis (Edinburgh, Scotland) · 2014Article
- Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice.The American journal of pathology · 2014Article
- MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein.BMC microbiology · 2013Article
- Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis.Cell communication and signaling : CCS · 2013Article
- Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection.Scientific reports · 2013Article
- Gene Expression Profiling of Tuberculous Meningitis Co-infected with HIV.Journal of proteomics & bioinformatics · 2012Article
- Dynamics of interferon-gamma release assay and cytokine profiles in blood and respiratory tract specimens from mice with tuberculosis and the effect of therapy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein.The Journal of biological chemistry · 2011Article
- Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis.Microbes and infection · 2011Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The complex molecular events that occur within the host during the establishment of a Mycobacterium tuberculosis infection are poorly defined, thus preventing identification of predictive markers of disease progression and state. To identify such molecular markers during M. tuberculosis infection, global changes in transcriptional response in the host were assessed using mouse whole genome arrays. Bacterial load in the lungs, the lesions associated with infection, and gene expression profiling was performed by comparing normal lung tissue to lungs from mice collected at 20, 40, and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis. Quantitative, whole lung gene expression identified signature profiles defining different signaling pathways and immunological responses characteristic of disease progression. This includes genes representing members of the interferon-associated gene families, chemokines and cytokines, MHC, and NOS2, as well as an array of cell surface markers associated with the activation of T cells, macrophages, and dendritic cells that participate in immunity to M. tuberculosis infection. More importantly, several gene transcripts encoding proteins that were not previously associated with the host response to M. tuberculosis infection, and unique molecular markers associated with disease progression and state, were identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.