ArticleProceedings of the National Academy of Sciences of the United States of America2008
CD4 memory T cells divide poorly in response to antigen because of their cytokine profile.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed.
- Deep Flow Cytometry Unveils Distinct Immune Cell Subsets in Inducible T Cell Co-Stimulator Ligand (ICOSL)- and ICOS-Knockout Mice during Experimental Autoimmune Encephalomyelitis.International journal of molecular sciences · 2024Article
- Preparation of Hypoallergenic Whey Protein Hydrolysate by a Mixture of Alcalase and Prozyme and Evaluation of Its Digestibility and Immunoregulatory Properties.Food science of animal resources · 2023Article
- Selective depletion of naïve T cells by targeting CD45RA.Frontiers in oncology · 2022Review
- The bovine dialysable leukocyte extract IMMUNEPOTENT CRP induces immunogenic cell death in breast cancer cells leading to long-term antitumour memory.British journal of cancer · 2021Article
- Tolerance induction in memory CD4 T cells is partial and reversible.Immunology · 2021Article
- Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity.Journal of cellular immunology · 2021Article
- The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer.Frontiers in oncology · 2021Article
- B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria.Virulence · 2020Article
- Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression.Cancer medicine · 2020Article
- B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.The Journal of experimental medicine · 2020Article
- Liver tissue metabolically transformed by alcohol induces immune recognition of liver self-proteins but not in vivo inflammation.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.JCI insight · 2018Article
- Peripheral CD4+ naïve/memory ratio is an independent predictor of survival in non-small cell lung cancer.Oncotarget · 2017Article
- Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection.Immunology · 2017Article
- CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients.JCI insight · 2017Article
- Chronic Plasmodium chabaudi Infection Generates CD4 Memory T Cells with Increased T Cell Receptor Sensitivity but Poor Secondary Expansion and Increased Apoptosis.Infection and immunity · 2017Article
- MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4⁺ T-cell priming.Mucosal immunology · 2015Article
- Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- KLRG+ invariant natural killer T cells are long-lived effectors.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated vaccines. The characteristics and functions of CD4 memory cells have not been well defined. Here we demonstrate that the increased size of the secondary response is solely a consequence of the increased antigen-specific precursor frequency within the memory pool. Memory cells proliferated less than primary responding cells, even within the same host. By analyzing the entry of primary and memory cells into the cell cycle, we found that the two populations proliferated similarly until day 5; after this time, fewer of the reactivated memory cells proliferated. At this time, fewer of the reactivated memory cells made IL-2 than primary responding cells, but more made IFNgamma. Both these factors affected the low proliferation of the memory cells, because either exogenous IL-2 or inhibition of IFNgamma increased the proliferation of the memory cells.
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