ArticleProceedings of the National Academy of Sciences of the United States of America2008
Quantitative visualization of passive transport across bilayer lipid membranes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Volatile fatty acids as sustainable precursors for bioproduction: advances in pathway engineering, and bioprocess optimization.World journal of microbiology & biotechnology · 2026Review
- A unique symbiosome in an anaerobic single-celled eukaryote.Nature communications · 2024Article
- Can Single Cell Respiration be Measured by Scanning Electrochemical Microscopy (SECM)?ACS measurement science au · 2023Article
- Synthesis and physicochemical characterization of acyl myricetins as potential anti-neuroexocytotic agents.Scientific reports · 2023Article
- Minimizing Experimental Testing on Fish for Legacy Pharmaceuticals.Environmental science & technology · 2023Article
- Multimodal Investigation into the Interaction of Quinacrine with Microcavity-Supported Lipid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Calculation of Permeability Coefficients from Solute Equilibration Dynamics: An Assessment of Various Methods.Membranes · 2022Article
- The role of noncoding RNAs in cancer lipid metabolism.Frontiers in oncology · 2022Review
- TCA Cycle Replenishing Pathways in Photosynthetic Purple Non-Sulfur Bacteria Growing with Acetate.Life (Basel, Switzerland) · 2021Review
- The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux.Chemical reviews · 2021Article
- Production of electricity and reduction of high-fat diet-induced IL-6 by glucose fermentation of Leuconostoc mesenteroides.Biochemical and biophysical research communications · 2020Article
- Acetate Metabolism and the Inhibition of Bacterial Growth by Acetate.Journal of bacteriology · 2019Article
- Article
- Overton's rule helps to estimate the penetration of anti-infectives into patients' cerebrospinal fluid.Antimicrobial agents and chemotherapy · 2012Article
- Imaging molecular transport across lipid bilayers.Biophysical journal · 2011Article
- Confocal imaging to quantify passive transport across biomimetic lipid membranes.Analytical chemistry · 2010Article
- Solid-state NMR spectroscopic studies on the interaction of sorbic acid with phospholipid membranes at different pH levels.Magnetic resonance in chemistry : MRC · 2009Article
- 110 years of the Meyer-Overton rule: predicting membrane permeability of gases and other small compounds.Chemphyschem : a European journal of chemical physics and physical chemistry · 2009Review
- High lipophilicity of perfluoroalkyl carboxylate and sulfonate: implications for their membrane permeability.Journal of the American Chemical Society · 2009Article
- Passive transport across bilayer lipid membranes: Overton continues to rule.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to predict and interpret membrane permeation coefficients is of critical importance, particularly because passive transport is crucial for the effective delivery of many pharmaceutical agents to intracellular targets. We present a method for the quantitative measurement of the permeation coefficients of protonophores by using laser confocal scanning microscopy coupled to microelectrochemistry, which is amenable to precise modeling with the finite element method. The technique delivers well defined and high mass transport rates and allows rapid visualization of the entire pH distribution on both the cis and trans side of model bilayer lipid membranes (BLMs). A homologous series of carboxylic acids was investigated as probe molecules for BLMs composed of soybean phosphatidylcholine. Significantly, the permeation coefficient decreased with acyl tail length contrary to previous work and to Overton's rule. The reasons for this difference are considered, and we suggest that the applicability of Overton's rule requires re-evaluation.
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