ArticleJournal of applied physiology (Bethesda, Md. : 1985)2008
Somatosensory feedback from the limbs exerts inhibitory influences on central neural drive during whole body endurance exercise.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Neuromuscular fatigue differences between prepubertal boys and men after maximal concentric versus eccentric isokinetic knee extensions.European journal of applied physiology · 2026Trial
- A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Acute effect of high-definition and conventional tDCS on exercise performance and psychophysiological responses in endurance athletes: a randomized controlled trial.Scientific reports · 2021Trial
- Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Repeated sprint training in normobaric hypoxia.British journal of sports medicine · 2013Trial
- Implications of group III and IV muscle afferents for high-intensity endurance exercise performance in humans.The Journal of physiology · 2011Trial
- Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans.The Journal of physiology · 2009Trial
- On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: role of muscle mass.The Journal of physiology · 2009Trial
- On the adaptive significance of group III/IV muscle afferent feedback for the cardiovascular response during sustained locomotion in humans.The Journal of physiology · 2026Article
- Obligatory neural feedback control of exercise cardiorespiratory function and performance.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Implications for the Ergogenic Benefits of Self-Selected Music in Neurological Conditions: A Theoretical Review.Neurology international · 2025Review
- Can alternative medical methods evoke somatosensory responses and functional improvement?Heliyon · 2024Review
- Exercise pressor responses are exaggerated relative to force production during, but not following, thirty-minutes of rhythmic handgrip exercise.European journal of applied physiology · 2024Article
- Autonomic cardiovascular control during exercise.American journal of physiology. Heart and circulatory physiology · 2023Review
- Perceptions of fatigue and neuromuscular measures of performance fatigability during prolonged low-intensity elbow flexions.Experimental physiology · 2023Article
- Neurovascular Dysregulation During Exercise in Type 2 Diabetes.Frontiers in physiology · 2021Review
- On the Influence of Group III/IV Muscle Afferent Feedback on Endurance Exercise Performance.Exercise and sport sciences reviews · 2020Review
- Mechanism of Fatigue Induced by Different Cycling Paradigms With Equivalent Dosage.Frontiers in physiology · 2020Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We investigated whether somatosensory feedback from contracting limb muscles exerts an inhibitory influence on the determination of central command during closed-loop cycling exercise in which the subject voluntarily determines his second-by-second central motor drive. Eight trained cyclists performed two 5-km time trials either without (5K(Ctrl)) or with lumbar epidural anesthesia (5K(Epi); 24 ml of 0.5% lidocaine, vertebral interspace L(3)-L(4)). Percent voluntary quadriceps muscle activation was determined at rest using a superimposed twitch technique. Epidural lidocaine reduced pretime trial maximal voluntary quadriceps strength (553 +/- 45 N) by 22 +/- 3%. Percent voluntary quadriceps activation was also reduced from 97 +/- 1% to 81 +/- 3% via epidural lidocaine, and this was unchanged following the 5K(Epi), indicating the presence of a sustained level of neural impairment throughout the trial. Power output was reduced by 9 +/- 2% throughout the race (P < 0.05). We found three types of significant effects of epidural lidocaine that supported a substantial role for somatosensory feedback from the exercising limbs as a determinant of central command throughout high-intensity closed-loop cycling exercise: 1) significantly increased relative integrated EMG of the vastus lateralis; 2) similar pedal forces despite the reduced number of fast-twitch muscle fibers available for activation; 3) and increased ventilation out of proportion to a reduced carbon dioxide production and heart rate and increased blood pressure out of proportion to power output and oxygen consumption. These findings demonstrate the inhibitory influence of somatosensory feedback from contracting locomotor muscles on the conscious and/or subconscious determination of the magnitude of central motor drive during high intensity closed-loop endurance exercise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.