ArticleMolecular endocrinology (Baltimore, Md.)2008
Rapid recruitment of temporally distinct vascular gene sets by estrogen.
Article in Molecular endocrinology (Baltimore, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Cis-regulatory control of transcriptional timing and noise in response to estrogen.Cell genomics · 2024Article
- Article
- Sex Differences, Estrogen Metabolism and Signaling in the Development of Pulmonary Arterial Hypertension.Frontiers in cardiovascular medicine · 2021Review
- The endothelial mineralocorticoid receptor: Contributions to sex differences in cardiovascular disease.Pharmacology & therapeutics · 2019Review
- Effect of chronic estradiol plus progesterone treatment on experimental arterial and venous thrombosis in mouse.PloS one · 2017Article
- The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.EMBO molecular medicine · 2014Article
- Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Sex differences in the human peripheral blood transcriptome.BMC genomics · 2014Article
- How Gene Networks Can Uncover Novel CVD Players.Current cardiovascular risk reports · 2014Article
- Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart.Physiological genomics · 2012Article
- Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury.Circulation · 2012Article
- SCOREM: statistical consolidation of redundant expression measures.Nucleic acids research · 2012Article
- Estrogen signaling and cardiovascular disease.Circulation research · 2011Review
- Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Placental growth factor mediates aldosterone-dependent vascular injury in mice.The Journal of clinical investigation · 2010Article
- Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment.Hippocampus · 2010Article
- Gender differences in cardiovascular disease: hormonal and biochemical influences.Reproductive sciences (Thousand Oaks, Calif.) · 2010Review
- Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2010Article
- This issue includes more than a conventional discussion of heart disease in women.Journal of cardiovascular translational research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Cardiovascular disease is the leading cause of mortality for both men and women in developed countries. The sex steroid hormone estrogen is required for normal vascular physiology. Estrogen functions by binding to intracellular estrogen receptors (ER), ERalpha and ERbeta, ligand-activated transcription factors that are expressed in both vascular endothelial and smooth muscle cells. We recently demonstrated that long-term (8 d) estrogen treatment in vivo in mice recruits distinct vascular gene sets mediated by ERalpha and ERbeta and that the promoters from these gene sets are enriched for binding sites of specific transcription factors, leading to the hypothesis that estrogen initiates a cascade of early transcriptional events that modulate gene expression in the vasculature. Here we test this hypothesis using gene expression profiling to examine initial transcriptional events (2-8 h) mediated by estrogen in blood vessels. Our data reveal that 1) estrogen regulates temporally distinct cascades of vascular gene expression, 2) initially, estrogen-mediated vascular gene repression predominates, 3) the earliest estrogen-recruited gene program is enriched in vascular transcription factors that can interact with binding sites present in estrogen-regulated vascular genes recruited subsequently, and 4) estrogen-regulated genes recruited next have specific functions, including lipid metabolism and cellular growth and proliferation that are potentially important for estrogen's known vascular functions. In summary, estrogen directly and rapidly recruits specific transcriptional factors that then propagate distinct cascades of gene expression. These data define the temporal recruitment of specific vascular genes by estrogen and enable further analysis of the mechanisms by which estrogen directly regulates vascular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.