ArticleEndocrinology2009
Role of aging versus the loss of estrogens in the reduction in vascular function in female rats.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- 17β-Estradiol Treatment Improves Acetylcholine-Induced Relaxation of Mesenteric Arteries in Ovariectomized UC Davis Type 2 Diabetes Mellitus Rats in Prediabetic State.Frontiers in physiology · 2022Article
- Promoting healthy cardiovascular aging: emerging topics.The journal of cardiovascular aging · 2022Article
- Heterogeneous effect of aging on vasorelaxation responses in large and small arteries.Physiological reports · 2020Article
- Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression.Molecular pharmacology · 2019Article
- 11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization.Journal of molecular and cellular cardiology · 2016Article
- Role of estrogen in diastolic dysfunction.American journal of physiology. Heart and circulatory physiology · 2014Review
- Antioxidative effect of aspirin on vascular function of aged ovariectomized rats.Age (Dordrecht, Netherlands) · 2014Article
- Efficacy of female rat models in translational cardiovascular aging research.Journal of aging research · 2014Review
- Aging, estrogen loss and epoxyeicosatrienoic acids (EETs).PloS one · 2013Article
- Influence of estradiol supplementation on neuropeptide Y neurotransmission in skeletal muscle arterioles of F344 rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Rapid activation of nuclear factor κB by 17β-estradiol and selective estrogen receptor modulators: pathways mediating cellular protection.Shock (Augusta, Ga.) · 2012Article
- Estrogen and the cardiovascular system.Pharmacology & therapeutics · 2012Review
- Differential modulation of nitric oxide synthases in aging: therapeutic opportunities.Frontiers in physiology · 2012Article
- Vascular Aging in Women: is Estrogen the Fountain of Youth?Frontiers in physiology · 2012Article
- RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase.Nitric oxide : biology and chemistry · 2011Review
- Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation.Physiological genomics · 2011Article
- 17β-Estradiol, aging, inflammation, and the stress response in the female heart.Endocrinology · 2011Article
- Endothelial dysfunction of resistance vessels in female apolipoprotein E-deficient mice.Lipids in health and disease · 2010Article
- Membrane-initiated actions of estrogen on the endothelium.Molecular and cellular endocrinology · 2009Review
- Age-related changes in dorsal root ganglia, circulating and vascular calcitonin gene-related peptide (CGRP) concentrations in female rats: effect of female sex steroid hormones.Neuroscience letters · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Although aging is known to lead to increased vascular stiffness, the role of estrogens in the prevention of age-related changes in the vasculature remains to be elucidated. To address this, we measured vascular function in the thoracic aorta in adult and old ovariectomized (ovx) rats with and without immediate 17beta-estradiol (E2) replacement. In addition, aortic mRNA and protein were analyzed for proteins known to be involved in vasorelaxation. Aging in combination with the loss of estrogens led to decreased vasorelaxation in response to acetylcholine and sodium nitroprusside, indicating either smooth muscle dysfunction and/or increased fibrosis. Loss of estrogens led to increased vascular tension in response to phenylephrine, which could be partially restored by E2 replacement. Levels of endothelial nitric oxide synthase and inducible nitric oxide synthase did not differ among the groups, nor did total nitrite plus nitrate levels. Old ovx exhibited decreased expression of both the alpha and beta-subunits of soluble guanylyl cyclase (sGC) and had impaired nitric oxide signaling in the vascular smooth muscle. Immediate E2 replacement in the aged ovx prevented both the impairment in vasorelaxation, and the decreased sGC receptor expression and abnormal sGC signaling within the vascular smooth muscle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.