ArticleEndocrinology2009
Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress.Journal of neuroendocrinology · 2026Article
- A Review on Drug Induced Obesity and Rodent Experimental Models of Obesity in Animals.Maedica · 2022Article
- Effect of Stressors on the mRNA Expressions of Neurosecretory Protein GL and Neurosecretory Protein GM in Chicks.Frontiers in physiology · 2022Article
- Review
- Article
- Sex-dependent effects of chronic variable stress on discrete corticotropin-releasing factor receptor 1 cell populations.Physiology & behavior · 2020Article
- Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones.Biology of sex differences · 2017Article
- Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis by gene targeting in mice.Frontiers in neuroendocrinology · 2015Review
- Patterns of Brain Activation and Meal Reduction Induced by Abdominal Surgery in Mice and Modulation by Rikkunshito.PloS one · 2015Article
- CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress.Frontiers in neuroscience · 2014Review
- Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice.Cellular and molecular neurobiology · 2012Article
- CRF-like diuretic hormone negatively affects both feeding and reproduction in the desert locust, Schistocerca gregaria.PloS one · 2012Article
- Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgery.Brain research · 2011Article
- Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei.Neuroscience letters · 2011Article
- Localization of nesfatin-1 neurons in the mouse brain and functional implication.Brain research · 2011Article
- CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.PloS one · 2011Article
- Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervals.Peptides · 2011Article
- Increased ghrelin sensitivity and calorie consumption in subordinate monkeys is affected by short-term astressin B administration.Endocrine · 2010Article
- Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in rats.Brain research · 2010Article
- Mice overexpressing corticotropin-releasing factor show brain atrophy and motor dysfunctions.Neuroscience letters · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a 16-h overnight fast and ip injection of gut hormones regulating food intake were compared in CRF-OE and wild type (WT) littermate mice along with brain Fos expression, circulating ghrelin levels, and gastric emptying of a nonnutrient meal. CRF-OE mice injected ip with saline showed a 47 and 44% reduction of 30-min and 4-h cumulative food intake response to an overnight fast, respectively, compared with WT. However, the 30-min food intake decrease induced by ip cholecystokinin (3 microg/kg) and increase by ghrelin (300 microg/kg) were similar in CRF-OE and WT mice. Overnight fasting increased the plasma total ghrelin to similar levels in CRF-OE and WT mice, although CRF-OE mice had a 2-fold reduction of nonfasting ghrelin levels. The number of Fos-immunoreactive cells induced by fasting in the arcuate nucleus was reduced by 5.9-fold in CRF-OE compared with WT mice whereas no significant changes were observed in other hypothalamic nuclei. In contrast, fasted CRF-OE mice displayed a 5.6-fold increase in Fos-immunoreactive cell number in the dorsal motor nucleus of the vagus nerve and a 34% increase in 20-min gastric emptying. These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response.
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Registered trials
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