ReviewCurrent biology : CB2008
A cyanobacterial circadian clockwork.
Review in Current biology : CB, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 94 citations in OpenAlex.
- Non-visual opsins and their role in circadian photoentrainment.Eye and vision (London, England) · 2026Review
- PERspectives on circadian cell biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Circadian regulation of physiology by disordered protein-protein interactions.Current opinion in structural biology · 2024Review
- Environmental F actors coordinate circadian clock function and rhythm to regulate plant development.Plant signaling & behavior · 2023Review
- The circadian clock ticks in plant stress responses.Stress biology · 2022Review
- The Dark Side of Microbial Processes: Accumulation of Nitrate During Storage of Surface Water in the Dark and the Underlying Mechanism.Microbiology spectrum · 2022Article
- Vertical stratification of the air microbiome in the lower troposphere.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Chronobiology Meets Quantum Biology: A New Paradigm Overlooking the Horizon?Frontiers in physiology · 2022Review
- Physiology of Methylotrophs Living in the Phyllosphere.Microorganisms · 2021Review
- The Circadian Clock Improves Fitness in the Fruit Fly,Frontiers in physiology · 2019Article
- Stable Reference Gene Selection for RT-qPCR Analysis inBioMed research international · 2019Article
- Timing the day: what makes bacterial clocks tick?Nature reviews. Microbiology · 2017Review
- Regulation of Mammalian Physiology by Interconnected Circadian and Feeding Rhythms.Frontiers in endocrinology · 2017Review
- The melatonin-sensitive circadian clock of the enteric bacterium Enterobacter aerogenes.Gut microbes · 2016Article
- A dynamic interaction process between KaiA and KaiC is critical to the cyanobacterial circadian oscillator.Scientific reports · 2016Article
- Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity.PloS one · 2016Article
- Metagenomic and lipid analyses reveal a diel cycle in a hypersaline microbial ecosystem.The ISME journal · 2015Article
- Circadian cycle-dependent MeCP2 and brain chromatin changes.PloS one · 2015Article
- Proteomics and circadian rhythms: it's all about signaling!Proteomics · 2015Review
- Chronopharmacology: new insights and therapeutic implications.Annual review of pharmacology and toxicology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cyanobacteria have become a major model system for analyzing circadian rhythms. The temporal program in this organism enhances fitness in rhythmic environments and is truly global--essentially all genes are regulated by the circadian system. The topology of the chromosome also oscillates and possibly regulates the rhythm of gene expression. The underlying circadian mechanism appears to consist of both a post-translational oscillator (PTO) and a transcriptional/translational feedback loop (TTFL). The PTO can be reconstituted in vitro with three purified proteins (KaiA, KaiB, and KaiC) and ATP. These three core oscillator proteins have been crystallized and structurally determined, the only full-length circadian proteins to be so characterized. The timing of cell division is gated by a circadian checkpoint, but the circadian pacemaker is not influenced by the status of the cell division cycle. This imperturbability may be due to the presence of the PTO that persists under conditions in which metabolism is repressed. Recent biochemical, biophysical, and structural discoveries have brought the cyanobacterial circadian system to the brink of explaining heretofore unexplainable biochemical characteristics of a circadian oscillator: the long time constant, precision, and temperature compensation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.