ArticleNeuron2008
Ca2+-dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin III.
Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Light adaptation of the microvillus refractory period in blow fly photoreceptors.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- The Role of Reversible Phosphorylation ofInternational journal of molecular sciences · 2022Review
- Molecular Evolution of Phototransduction Pathway Genes in Nocturnal and Diurnal Fireflies (Coleoptera: Lampyridae).Insects · 2021Article
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- One Actor, Multiple Roles: The Performances of Cryptochrome inFrontiers in physiology · 2020Review
- Evolution of Phototransduction Genes in Lepidoptera.Genome biology and evolution · 2019Article
- Fast intensity adaptation enhances the encoding of sound in Drosophila.Nature communications · 2018Article
- Cryptochrome Interacts With Actin and Enhances Eye-Mediated Light Sensitivity of the Circadian Clock inFrontiers in molecular neuroscience · 2018Article
- Functional interplay of visual, sensitizing and screening pigments in the eyes of Drosophila and other red-eyed dipteran flies.The Journal of physiology · 2017Review
- A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range.The Journal of physiology · 2017Review
- Electrophysiological Method for Whole-cell Voltage Clamp Recordings from Drosophila Photoreceptors.Journal of visualized experiments : JoVE · 2017Article
- Insect photoreceptor adaptations to night vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Ectopic Expression of Mouse Melanopsin inThe Journal of biological chemistry · 2017Article
- In vivo tracking of phosphoinositides in Drosophila photoreceptors.Journal of cell science · 2015Article
- Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.PLoS biology · 2015Article
- Calcium activates the light-dependent conductance in melanopsin-expressing photoreceptors of amphioxus.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Arrestins: Critical Players in Trafficking of Many GPCRs.Progress in molecular biology and translational science · 2015Review
- Elementary and macroscopic light-induced currents and their Ca(2+)-dependence in the photoreceptors of Periplaneta americana.Frontiers in physiology · 2014Article
- Rhodopsin homeostasis and retinal degeneration: lessons from the fly.Trends in neurosciences · 2013Review
- Fractional Ca(2+) currents through TRP and TRPL channels in Drosophila photoreceptors.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Phototransduction in flies is the fastest known G protein-coupled signaling cascade, but how this performance is achieved remains unclear. Here, we investigate the mechanism and role of rhodopsin inactivation. We determined the lifetime of activated rhodopsin (metarhodopsin = M( *)) in whole-cell recordings from Drosophila photoreceptors by measuring the time window within which inactivating M( *) by photoreisomerization to rhodopsin could suppress responses to prior illumination. M( *) was inactivated rapidly (tau approximately 20 ms) under control conditions, but approximately 10-fold more slowly in Ca2+-free solutions. This pronounced Ca2+ dependence of M( *) inactivation was unaffected by mutations affecting phosphorylation of rhodopsin or arrestin but was abolished in mutants of calmodulin (CaM) or the CaM-binding myosin III, NINAC. This suggests a mechanism whereby Ca2+ influx acting via CaM and NINAC accelerates the binding of arrestin to M( *). Our results indicate that this strategy promotes quantum efficiency, temporal resolution, and fidelity of visual signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.