ArticleNeuron2008
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes.
Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers.
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Who cites it
201 citing papers in PubMed.
- Directing GABAergic neuronal identity from human iPSCs through developmental patterning.Stem cell reports · 2026Article
- Foxe1 deficiency impairs thyroid fate while supporting lung differentiation.EMBO reports · 2026Article
- Hypoxia-inducible factor signaling regulates embryonic interneuron development, GRIN2B expression and adult cortical function.Developmental cell · 2026Article
- Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Dual developmental effects of ARX poly-alanine mutations on human cortical excitatory and inhibitory neurons.Cell reports · 2026Article
- NKX2-1 drives neuroendocrine transdifferentiation of prostate cancer via epigenetic and 3D chromatin remodeling.Nature genetics · 2025Article
- Experience-Dependent Intrinsic Plasticity in Layer IV of Barrel Cortex at Whisking Onset.eNeuro · 2025Article
- Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding.Nature communications · 2025Article
- Immediately following the onset of active whisking, the input layer of barrel cortex exhibits a transient period of increased excitability that depends on prior experience.bioRxiv : the preprint server for biology · 2025Article
- Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long-term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets.Journal of anatomy · 2025Article
- Both GEF domains of the autism and developmental epileptic encephalopathy-associated Trio protein are required for proper tangential migration of GABAergic interneurons.Molecular psychiatry · 2025Article
- Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling.Nature communications · 2025Article
- Fast-spiking parvalbumin-positive interneurons: new perspectives of treatment and future challenges in dementia.Molecular psychiatry · 2025Review
- Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains.Nature communications · 2025Article
- Differential diagnosis of Huntington's disease- neurological aspects of NKX2-1-related disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- The molecular and cellular choreography of early mammalian lung development.Medical review (2021) · 2024Review
- GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024Review
- Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories.Neuron · 2024Article
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.Developmental biology · 2023Article
141 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
Previous work has demonstrated that the character of mouse cortical interneuron subtypes can be directly related to their embryonic temporal and spatial origins. The relationship between embryonic origin and the character of mature interneurons is likely reflected by the developmental expression of genes that direct cell fate. However, a thorough understanding of the early genetic events that specify subtype identity has been hampered by the perinatal lethality resulting from the loss of genes implicated in the determination of cortical interneurons. Here, we employ a conditional loss-of-function approach to demonstrate that the transcription factor Nkx2-1 is required for the proper specification of specific interneuron subtypes. Removal of this gene at distinct neurogenic time points results in a switch in the subtypes of neurons observed at more mature ages. Our strategy reveals a causal link between the embryonic genetic specification by Nkx2-1 in progenitors and the functional attributes of their neuronal progeny in the mature nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.