ArticleBMC pediatrics2008
Screening rules for growth to detect celiac disease: a case-control simulation study.
Article in BMC pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- From genes to environment: A life-course approach to prevent pediatric autoimmune diseases.World journal of clinical pediatrics · 2026Review
- Growth patterns in coeliac disease - a longitudinal study of children aged 0-6 years in Sweden.BMC pediatrics · 2026Observational
- Nutritional Status and Metabolism in Celiac Disease: Narrative Review.Journal of clinical medicine · 2023Review
- The Effect of Gluten-Free Diet Duration on Body Mass Index of Iranian Patients with Celiac Disease.Middle East journal of digestive diseases · 2022Article
- Delphi consensus on the diagnosis and treatment of patients with short stature in Spain: GROW-SENS study.Journal of endocrinological investigation · 2022Article
- The Gluten Free Diet's Impact on Growth in Children with Celiac Disease in Two Different Countries.Nutrients · 2020Article
- Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children.Digestive diseases and sciences · 2019Article
- Growth changes after gluteen free diet in pediatric celiac patients: a literature-review.Acta bio-medica : Atenei Parmensis · 2018Review
- The identification of celiac disease in asymptomatic children: the Generation R Study.Journal of gastroenterology · 2018Article
- Growth monitoring: a survey of current practices of primary care paediatricians in Europe.PloS one · 2013Article
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is generally assumed that most patients with celiac disease (CD) have a slowed growth in terms of length (or height) and weight. However, the effectiveness of slowed growth as a tool for identifying children with CD is unknown. Our aim is to study the diagnostic efficiency of several growth criteria used to detect CD children.
methodsA case-control simulation study was carried out. Longitudinal length and weight measurements from birth to 2.5 years of age were used from three groups of CD patients (n = 134) (one group diagnosed by screening, two groups with clinical manifestations), and a reference group obtained from the Social Medical Survey of Children Attending Child Health Clinics (SMOCC) cohort (n = 2,151) in The Netherlands. The main outcome measures were sensitivity, specificity and positive predictive value (PPV) for each criterion.
resultsBody mass index (BMI) performed best for the groups with clinical manifestations. Thirty percent of the CD children with clinical manifestations and two percent of the reference children had a BMI Standard Deviation Score (SDS) less than -1.5 and a decrease in BMI SDS of at least -2.5 (PPV = 0.85%). The growth criteria did not discriminate between the screened CD group and the reference group.
conclusionFor the CD children with clinical manifestations, the most sensitive growth parameter is a decrease in BMI SDS. BMI is a better predictor than weight, and much better than length or height. Toddlers with CD detected by screening grow normally at this stage of the disease.
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