ArticleMolecular microbiology2008
Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Cell cycle dependent coordination of surface layer biogenesis in Caulobacter crescentus.Nature communications · 2024Article
- DNA-Binding Properties of YbaB, a Putative Nucleoid-Associated Protein FromFrontiers in microbiology · 2021Article
- An Essential Regulator of Bacterial Division Links FtsZ to Cell Wall Synthase Activation.Current biology : CB · 2019Article
- Amidase activity is essential for medial localization of AmiC in Caulobacter crescentus.Current genetics · 2018Article
- FzlA, an essential regulator of FtsZ filament curvature, controls constriction rate during Caulobacter division.Molecular microbiology · 2018Article
- Shapeshifting to Survive: Shape Determination and Regulation in Caulobacter crescentus.Trends in microbiology · 2017Review
- Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis.The EMBO journal · 2017Article
- A New Essential Cell Division Protein in Caulobacter crescentus.Journal of bacteriology · 2017Article
- LipidII: Just Another Brick in the Wall?PLoS pathogens · 2015Review
- Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Diverse functions for six glycosyltransferases in Caulobacter crescentus cell wall assembly.Journal of bacteriology · 2013Article
- Cortex synthesis during Bacillus subtilis sporulation depends on the transpeptidase activity of SpoVD.FEMS microbiology letters · 2013Article
- Divin: a small molecule inhibitor of bacterial divisome assembly.Journal of the American Chemical Society · 2013Article
- Targeting of PBP1 by β-lactams determines recA/SOS response activation in heterogeneous MRSA clinical strains.PloS one · 2013Article
- Osmolality-dependent relocation of penicillin-binding protein PBP2 to the division site in Caulobacter crescentus.Journal of bacteriology · 2012Article
- Subnuclear development of the zebrafish habenular nuclei requires ER translocon function.Developmental biology · 2011Article
- A DNA damage checkpoint in Caulobacter crescentus inhibits cell division through a direct interaction with FtsW.Genes & development · 2011Article
- Assembly of the Caulobacter cell division machine.Molecular microbiology · 2011Article
- Advances in understanding E. coli cell fission.Current opinion in microbiology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In rod-shaped bacteria, septal peptidoglycan synthesis involves the late recruitment of the ftsI gene product (PBP3 in Escherichia coli) to the FtsZ ring. We show that in Caulobacter crescentus, PBP3 accumulates at the new pole at the beginning of the cell cycle. Fluorescence recovery after photobleaching experiments reveal that polar PBP3 molecules are, constantly and independently of FtsZ, replaced by those present in the cellular pool, implying that polar PBP3 is not a remnant of the previous division. By the time cell constriction is initiated, all PBP3 polar accumulation has disappeared in favour of an FtsZ-dependent localization near midcell, consistent with PBP3 function in cell division. Kymograph analysis of time-lapse experiments shows that the recruitment of PBP3 to the FtsZ ring is progressive and initiated very early on, shortly after FtsZ ring formation and well before cell constriction starts. Accumulation of PBP3 near midcell is also highly dynamic with a rapid exchange of PBP3 molecules between midcell and cellular pools. Localization of PBP3 at both midcell and pole appears multifactorial, primarily requiring the catalytic site of PBP3. Collectively, our results suggest a role for PBP3 in pole morphogenesis and provide new insights into the process of peptidoglycan assembly during division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.