ArticleTraffic (Copenhagen, Denmark)2008
Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb.
Article in Traffic (Copenhagen, Denmark), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Class A and B GPCRs trigger rapid GαCommunications biology · 2025Article
- β-Adrenergic control of sarcolemmal CaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- β2-Adrenergic receptor activation on donor cells ameliorates acute GvHD.JCI insight · 2020Article
- Roles of Myosin-Mediated Membrane Trafficking in TGF-β Signaling.International journal of molecular sciences · 2019Review
- Rapid Turnover of the Cardiac L-Type CaiScience · 2018Article
- Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling.The Journal of cell biology · 2015Article
- Src regulates sequence-dependent beta-2 adrenergic receptor recycling via cortactin phosphorylation.Traffic (Copenhagen, Denmark) · 2014Article
- Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis.PLoS genetics · 2014Article
- Αvβ3-integrin-mediated adhesion is regulated through an AAK1L- and EHD3-dependent rapid-recycling pathway.Journal of cell science · 2013Article
- MYO5B is epigenetically silenced and associated with MET signaling in human gastric cancer.Digestive diseases and sciences · 2013Article
- Transcriptomic analysis of brown adipose tissue across the physiological extremes of natural hibernation.PloS one · 2013Article
- The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin.Molecular pharmaceutics · 2012Article
- Genetically encoded pH sensor for tracking surface proteins through endocytosis.Angewandte Chemie (International ed. in English) · 2012Article
- Inactivation of MYO5B promotes invasion and motility in gastric cancer cells.Digestive diseases and sciences · 2012Article
- The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.PloS one · 2012Article
- Rab11a and its binding partners regulate the recycling of the ß1-adrenergic receptor.Cellular signalling · 2011Article
- Cdx2 regulates endo-lysosomal function and epithelial cell polarity.Genes & development · 2010Article
- The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility.Traffic (Copenhagen, Denmark) · 2010Article
- Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface.The Journal of biological chemistry · 2009Article
- The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.The EMBO journal · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
For the beta(2)-adrenergic receptor (beta(2)AR), published evidence suggests that an intact actin cytoskeleton is required for the endocytosis of receptors and their proper sorting to the rapid recycling pathway. We have characterized the role of the actin cytoskeleton in the regulation of beta(2)AR trafficking in human embryonic kidney 293 (HEK293) cells using two distinct actin filament disrupting compounds, cytochalasin D and latrunculin B (LB). In cells pretreated with either drug, beta(2)AR internalization into transferrin-positive vesicles was not altered but both agents significantly decreased the rate at which beta(2)ARs recycled to the cell surface. In LB-treated cells, nonrecycled beta(2)ARs were localized to early embryonic antigen 1-positive endosomes and also accumulated in the recycling endosome (RE), but only a small fraction of receptors localized to LAMP-positive late endosomes and lysosomes. Treatment with LB also markedly enhanced the inhibitory effect of rab11 overexpression on receptor recycling. Dissociating receptors from actin by expression of the myosin Vb tail fragment resulted in missorting of beta(2)ARs to the RE, while the expression of various CART fragments or the depletion of actinin-4 had no detectable effect on beta(2)AR sorting. These results indicate that the actin cytoskeleton is required for the efficient recycling of beta(2)ARs, a process that likely is dependent on myosin Vb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.