ArticleWorld journal of gastroenterology2008
Active Chinese mistletoe lectin-55 enhances colon cancer surveillance through regulating innate and adaptive immune responses.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
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- Review
- Component Composition and Features of Biological Activity of Viscum album (Viscaceae).Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2024Review
- The potential of plant extracts in cell therapy.Stem cell research & therapy · 2022Review
- Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells.Frontiers in pharmacology · 2020Review
- Comparative Evaluation of Soluble and Insoluble-Bound Phenolics and Antioxidant Activity of Two Chinese Mistletoes.Molecules (Basel, Switzerland) · 2018Article
- Plant Lectins as Medical Tools against Digestive System Cancers.International journal of molecular sciences · 2017Review
- Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review.British journal of pharmacology · 2017Review
- Efficacy of traditional Chinese medicine in treating cancer.Biomedical reports · 2016Article
- Emerging roles of mistletoes in malignancy management.3 Biotech · 2014Article
- Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential.Chinese medicine · 2014Review
- Mistletoe lectin has a shiga toxin-like structure and should be combined with other Toll-like receptor ligands in cancer therapy.Cancer immunology, immunotherapy : CII · 2013Article
- Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the potential role of active Chinese mistletoe lectin-55 (ACML-55) in tumor immune surveillance.
methodsIn this study, an experimental model was established by hypodermic inoculating the colon cancer cell line CT26 (5 x 10(5) cells) into BALB/c mice. The experimental treatment was orally administered with ACML-55 or PBS, followed by the inoculation of colon cancer cell line CT26. Intracellular cytokine staining was used to detect IFN-gamma production by tumor antigen specific CD8+ T cells. FACS analysis was employed to profile composition and activation of CD4+, CD8+, gammadelta T and NK cells.
resultsOur results showed, compared to PBS treated mice, ACML-55 treatment significantly delayed colon cancer development in colon cancer-bearing Balb/c mice in vivo. Treatment with ACML-55 enhanced both Ag specific activation and proliferation of CD4+ and CD8+ T cells, and increased the number of tumor Ag specific CD8+ T cells. It was more important to increase the frequency of tumor Ag specific IFN-gamma producing-CD8+ T cells. Interestingly, ACML-55 treatment also showed increased cell number of NK, and gammadeltaT cells, indicating the role of ACML-55 in activation of innate lymphocytes.
conclusionOur results demonstrate that ACML-55 therapy can enhance function in immune surveillance in colon cancer-bearing mice through regulating both innate and adaptive immune responses.
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