ReviewHuman genetics2008
Human hereditary hearing impairment: mouse models can help to solve the puzzle.
Review in Human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans.Laboratory animal research · 2023Review
- Article
- Loss-of-function mutations of ILDR1 cause autosomal-recessive hearing impairment DFNB42.American journal of human genetics · 2011Article
- The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?Biochemical pharmacology · 2009Review
- Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans.American journal of human genetics · 2009Article
- Inheritance patterns of progressive hearing loss in laboratory strains of mice.Brain research · 2009Review
- Rethinking how hearing happens.Neuron · 2009Article
- Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse models are important research tools in the discovery of genes for syndromic as well as non-syndromic forms of hearing impairment. The similarity between the human and mouse inner ear, as well as the high homology between the human and mouse genome, make the mouse an excellent tool for genetic research on hearing loss. Over the past ten years, multiple mouse models for human hereditary hearing loss have been identified. The current review discusses the models according to the biological process in which they are involved. We review mouse models for genes involved in acellular matrix composition, hair bundle formation and maintenance, outer hair cell electromotility, the hair cell ribbon synapse and auditory nerve transmission, regulation of cochlear homeostasis and regulation of transcription. We have opted to put most emphasis on mouse models for non-syndromic forms of human hearing loss. However, we also discuss advances made in the field of age related hearing impairment by the use of mouse models and modifiers of hearing loss genes identified in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.