ArticleEuropean journal of applied physiology2008
Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise.
Article in European journal of applied physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
- Blood-Based Biomarkers for Managing Workload in Athletes: Perspectives for Research on Emerging Biomarkers.Sports medicine (Auckland, N.Z.) · 2023Review
- nNOS Increases Fiber Type-Specific Angiogenesis in Skeletal Muscle of Mice in Response to Endurance Exercise.International journal of molecular sciences · 2023Article
- Thermal dysregulation in patients with multiple sclerosis during SARS-CoV-2 infection. The potential therapeutic role of exercise.Multiple sclerosis and related disorders · 2022Review
- Heat therapy: mechanistic underpinnings and applications to cardiovascular health.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Review
- Effects of interval training on cardio metabolic risk factors and nitric oxide in type 2 diabetes patients: a randomized controlled trial.Journal of diabetes and metabolic disorders · 2020Article
- Voluntary Wheel Running Attenuates Salt-Induced Vascular Stiffness Independent of Blood Pressure.American journal of hypertension · 2019Article
- Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism.The Journal of biological chemistry · 2019Article
- Myosin: Formation and maintenance of thick filaments.Animal science journal = Nihon chikusan Gakkaiho · 2019Review
- Molecular regulation of skeletal muscle mass and the contribution of nitric oxide: A review.FASEB bioAdvances · 2019Article
- Muscle Recovery Is Highlighted by IR Laser Therapy.Journal of lasers in medical sciences · 2019Article
- Serum from young, sedentary adults who underwent passive heat therapy improves endothelial cell angiogenesis via improved nitric oxide bioavailability.Temperature (Austin, Tex.) · 2019Article
- TheBiology of sport · 2018Article
- Neuronal nitric oxide synthase regulation of skeletal muscle functional hyperemia: exercise training and moderate compensated heart failure.Nitric oxide : biology and chemistry · 2018Article
- Meta-inflammation and cardiometabolic disease in obesity: Can heat therapy help?Temperature (Austin, Tex.) · 2018Review
- Ten days of repeated local forearm heating does not affect cutaneous vascular function.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Relation between change in exercise capacity and change in blood amino acids in patients with chronic heart failure.Journal of physical therapy science · 2017Article
- Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans.The Journal of physiology · 2016Article
- Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Alterations in redox homeostasis in the elite endurance athlete.Sports medicine (Auckland, N.Z.) · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Exercise training results in dynamic changes in skeletal muscle blood flow and metabolism. Nitric oxide (NO) influences blood flow, oxidative stress, and glucose metabolism. Hsp90 interacts directly with nitric oxide synthases (NOS), increasing NOS activity and altering the balance of superoxide versus NO production. In addition, Hsp90 expression increases in various tissues following exercise. Therefore, we tested the hypothesis that exercise training increases Hsp90 expression as well as Hsp90/NOS association and NOS activity in skeletal muscle. Male, Sprague-Dawley rats were assigned to either a sedentary or exercise trained group (n = 10/group). Exercise training consisted of running on a motorized treadmill for 10 weeks at 30 m/min, 5% grade for 1 h. Western blotting revealed that exercise training resulted in a 1.9 +/- 0.1-fold increase in Hsp90 expression in the soleus muscle but no increase in neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase, or endothelial nitric oxide synthase (eNOS). Exercise training also resulted in a 3.4 +/- 1.0-fold increase in Hsp90 association with nNOS, a 2.3 +/- 0.4-fold increase association with eNOS measured by immunoprecipitation as well as a 1.5 +/- 0.3-fold increase in eNOS phosphorylation at Ser-1179. Total NOS activity measured by the rate of conversion of L-[(14)C]arginine to L-[(14)C]citrulline was increased by 1.42 +/- 0.9 fold in soleus muscle following exercise training compared to controls. In summary, a 10-week treadmill training program in rats results in a significant increase in total NOS activity in the soleus which may be due, in part, to increased NOS interaction with Hsp90 and phosphorylation. This interaction may play a role in altering muscle blood flow and skeletal muscle redox status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.