ArticleInternational ophthalmology2009
Intraepithelial and invasive squamous neoplasms of the conjunctiva in Ibadan, Nigeria: a clinicopathological study of 46 cases.
Article in International ophthalmology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Epidemiology of ocular surface squamous neoplasia in Africa.Tropical medicine & international health : TM & IH · 2013Pooled it
- Topical fluorouracil after surgery for ocular surface squamous neoplasia in Kenya: a randomised, double-blind, placebo-controlled trial.The Lancet. Global health · 2016Trial
- Rational Drug Use in Extraocular SurgeriesTurkish journal of ophthalmology · 2025Review
- Review
- Clinicopathological characteristics of ocular surface squamous neoplasia: a 10-year review form a referral tertiary centre in Nigeria.International ophthalmology · 2022Article
- Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: a 10-year review.International ophthalmology · 2021Article
- Comparative evaluation of clinical characteristics of biopsy-proven conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma using image processing software programs.International ophthalmology · 2021Article
- Human papillomavirus infection and ocular surface disease (Review).International journal of oncology · 2019Review
- Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana.Health science reports · 2019Article
- Observational
- Topical chemotherapy for giant ocular surface squamous neoplasia of the conjunctiva and cornea: Is surgery necessary?Indian journal of ophthalmology · 2018Article
- Delay along the care-seeking journey of patients with ocular surface squamous neoplasia in Kenya.BMC health services research · 2017Article
- A case of conjunctival mucoepidermoid carcinoma in Australia.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
- [Invasive squamous cell carcinoma of the conjunctiva].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2013Article
- Histochemical analysis and immunohistochemical profile of mucoepidermoid carcinoma of the conjunctiva.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2012Article
- Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia.Eye (London, England) · 2012Review
- Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa.Current opinion in oncology · 2010Review
- Prevalence and Severity of Ocular Surface Neoplasia in African Nations and Need for Early Interventions.Journal of ophthalmic & vision researchReview
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTo retrospectively evaluate the clinicopathological features, treatment modalities and factors affecting prognosis in patients with both conjunctival intraepithelial and invasive squamous neoplasms.
methodReview and analysis of clinical and pathological records of all cases histologically diagnosed in the Department of Pathology, University College Hospital, Ibadan, Nigeria between January 1990 and December 2004.
resultsThere were a total of 46 cases in 45 patients (eight intraepithelial carcinomas, 37 invasive squamous cell carcinomas (SCC) and a single case of mucoepidermoid carcinoma in a 71-year-old man). The intraepithelial neoplasms occurred in patients aged between 20 and 90 years. Seven of these patients had actinic changes on histology. For invasive SCC, patients' ages ranged from 18 to 84 years with a mean age of 53 years. Male to female ratio was 1:1. The majority presented with an orbital mass and loss of vision. Twenty-two (60%) of the patients with invasive SCC had enucleation or exenteration as the primary modality of treatment with or without radiotherapy or chemotherapy. Altogether for intraepithelial and invasive squamous neoplasms, the duration of presenting complaints ranged from 1 month to 5 years with an average of 2 years. Human immunodeficiency virus (HIV) infection and smoking were not significantly associated with these cases but a significant number had outdoor occupation. Low socioeconomic status and inability to afford treatment was common among our patients.
conclusionPatients with invasive SCC in Nigeria present late and have significant delay before having any form of treatment. This contributes to the poor outcome. Human papilloma virus (HPV) and actinic aetiology are possible strong causative agents in Nigerians.
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