ArticlePloS one2008
Tumor growth decreases NK and B cells as well as common lymphoid progenitor.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of Tai Chi on mononuclear cell functions in patients with non-small cell lung cancer.BMC complementary and alternative medicine · 2015Trial
- Pancreatic cancer induces B cell lineage plasticity via Pax5 inhibition to sustain immunosuppression.Cell death discovery · 2026Article
- S100A8/A9-amplified inflammation (TNF-α/IL-1β) in the bone marrow of tumor-bearing host disrupts early B cell development.Cell & bioscience · 2026Article
- Local M1 Macrophage Reprogramming with Gluconic Acid-Coated Selenium Nanoparticles.International journal of nanomedicine · 2025Article
- Alterations in Peripheral Lymphocyte Subsets under Immunochemotherapy in Stage IV SCLC Patients: Th17 Cells as Potential Early Predictive Biomarker for Response.International journal of molecular sciences · 2024Article
- Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression.Frontiers in immunology · 2022Review
- Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes.Oncoimmunology · 2020Article
- NK Cell Plasticity in Cancer.Journal of clinical medicine · 2019Review
- Cell circuits and niches controlling B cell development.Immunological reviews · 2019Review
- Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth.Oncotarget · 2017Article
- The breast tumor microenvironment alters the phenotype and function of natural killer cells.Cellular & molecular immunology · 2016Article
- Tumor-primed NK cells: waiting for the green light.Frontiers in immunology · 2013Review
- Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1.Journal of oncology · 2012Article
- Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity.Clinical & experimental metastasis · 2011Article
- The Role of Nuclear Factor-κB in Cancer Immunity and Immunoediting.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIt is well established that chronic tumor growth results in functional inactivation of T cells and NK cells. It is less clear, however, whether lymphopoeisis is affected by tumor growth. PRINCIPAL
findingsIn our efforts of analyzing the impact of tumor growth on NK cell development, we observed a major reduction of NK cell numbers in mice bearing multiple lineages of tumor cells. The decrease in NK cell numbers was not due to increased apoptosis or decreased proliferation in the NK compartment. In addition, transgenic expression of IL-15 also failed to rescue the defective production of NK cells. Our systematic characterization of lymphopoeisis in tumor-bearing mice indicated that the number of the common lymphoid progenitor was significantly reduced in tumor-bearing mice. The number of B cells also decreased substantially in tumor bearing mice. CONCLUSIONS AND SIGNIFICANCE: Our data reveal a novel mechanism for tumor evasion of host immunity and suggest a new interpretation for the altered myeloid and lymphoid ratio in tumor bearing hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.