ArticleGenes and immunity2008
Defining a transcriptional fingerprint of murine splenic B-cell development.
Article in Genes and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Formation of the intestinal microbiota during mouse weaning promotes maturation of the IgA repertoire after growth.Bioscience of microbiota, food and health · 2025Article
- Functional characterization and genomic studies of a novel murine submandibular gland epithelial cell line.PloS one · 2018Article
- The Role of TLR4 on B Cell Activation and Anti-Journal of immunology research · 2016Review
- Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.Frontiers in immunology · 2015Article
- Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins.International immunology · 2013Article
- The in vitro derivation of phenotypically mature and diverse B cells from immature spleen and bone marrow precursors.European journal of immunology · 2010Article
- CD21 signaling via C3 regulates Purkinje cell protein 4 expression.Molecular immunology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
B-cell development occurs in a stepwise fashion that can be followed by the expression of B cell-specific surface markers. In this study, we wished to identify proteins that could contribute to the changes in expression of such markers. By using RNA from freshly isolated B220+ cells, we hoped to reduce the effect of artifacts that occur during the isolation and amplification steps necessary to use flow cytometry analysis-sorted subsets in microarray experiments. Analyses comparing expression patterns from B220+ 2-week bone marrow (pro-B, pre-B, immature B cells), 2-week spleen (predominantly transitional cells) and 8-week spleen (mainly mature B cells) yielded hundreds of genes. We also examined the B cell-activating factor (BAFF)-dependent effects on immature splenic B cells by comparing expression patterns in the spleen between 2-week A/J vs 2-week A/WySnJ mice, which lack functional BAFF receptor signaling. Genes that showed the expression differences between spleen and bone marrow samples were then analyzed through quantitative PCR on B-cell subsets isolated using two different sorting protocols. A comparison of the results from our study with the results from other analyses showed not only some overlap of preferentially expressed genes but also an expansion of other genes potentially involved in B-cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.