Evidence map›Paper›PMID 18784454›Full record

ReviewAIDS (London, England)2008

A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle.

Charles R Wira, John V Fahey

Abstract readEditorialReview
In one paragraph

Review in AIDS (London, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Genital Tract and Circulating CD8+ T Cell Phenotypes Vary Across the Menstrual Cycle.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Article
  9. Review
  10. Review
  11. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  12. T-Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  13. Review
  14. Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  15. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  16. Review
  17. Frontiers in microbiology · 2026
    Review
  18. Review
  19. HIV-Exposed Seronegative Female Sex Workers Show Different Cellular Immune Profiles Across the Menstrual Cycle.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
  20. Review

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Charles R Wira
John V Fahey

Funding

The influence of steroid sex hormones and gender on pmnP01AI051877 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2002 to 2006
$7.4M
Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsR01AI071761 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2007 to 2014
$2.6M
SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEMR37AI013541 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 1997 to 2005
$2.1M
SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEMR01AI013541 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 1985 to 2011
$2.0M
Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsR56AI071761 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2007 to 2007
$167k
SEX HORMONE REGULATION OF THE MUCOSAL IMMUNE SYSTEMR55AI013541 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 1991 to 1991
–
NIAID NIH HHS AI-071761NIAID NIH HHS AI-13541NIAID NIH HHS AI-51877NIAID NIH HHS P01 AI051877NIAID NIH HHS R01 AI013541NIAID NIH HHS R01 AI071761NIAID NIH HHS R37 AI013541NIAID NIH HHS R56 AI071761
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HIV-1Contraceptives, Oral, HormonalDisease SusceptibilityFemaleGenitalia, FemaleGonadal Steroid HormonesHIV InfectionsHumansMenstrual CycleContraceptives, Oral, HormonalGonadal Steroid Hormones

Identifiers

PMID18784454
PMCPMC2647143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.