ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models.Fluids and barriers of the CNS · 2026Article
- The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies.International journal of molecular sciences · 2024Review
- CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy.Journal of experimental & clinical cancer research : CR · 2023Article
- Claudins in kidney health and disease.Kidney research and clinical practice · 2022Article
- Review
- CLDN6: From Traditional Barrier Function to Emerging Roles in Cancers.International journal of molecular sciences · 2021Review
- Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Magnesium Handling in the Kidney.Advances in chronic kidney disease · 2018Review
- Intestinal absorption and renal reabsorption of calcium throughout postnatal development.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Developmental changes in renal tubular transport-an overview.Pediatric nephrology (Berlin, Germany) · 2015Review
- Emerging multifunctional roles of Claudin tight junction proteins in bone.Endocrinology · 2014Review
- Claudins and the modulation of tight junction permeability.Physiological reviews · 2013Review
- Activation of the Ca(2+)-sensing receptor increases renal claudin-14 expression and urinary Ca(2+) excretion.American journal of physiology. Renal physiology · 2013Article
- Claudins and the kidney.Annual review of physiology · 2013Review
- Claudin-4 forms a paracellular barrier, revealing the interdependence of claudin expression in the loose epithelial cell culture model opossum kidney cells.American journal of physiology. Cell physiology · 2012Article
- The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells.International journal of cell biology · 2012Article
- Claudins in renal physiology and disease.Pediatric nephrology (Berlin, Germany) · 2011Review
- Tight junction pore and leak pathways: a dynamic duo.Annual review of physiology · 2011Review
- A claudin-9-based ion permeability barrier is essential for hearing.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The neonatal proximal tubule has a lower permeability to chloride, higher resistance, and higher relative sodium-to-chloride permeability (P(Na)/P(Cl)) than the adult tubule, which may be due to maturational changes in the tight junction. Claudins are tight-junction proteins between epithelial cells that determine paracellular permeability characteristics of epithelia. We have previously described the presence of two claudin isoforms, claudins 6 and 9, in the neonatal proximal tubule and subsequent reduction of these claudins during postnatal maturation. The question is whether changes in claudin expression are related to changes in functional characteristics in the neonatal tubule. We transfected claudins 6 and 9 into Madin-Darby canine kidney II (MDCK II) cells and performed electrophysiological studies to determine the resultant changes in physiological characteristics of the cells. Expression of claudins 6 and 9 resulted in an increased transepithelial resistance, decreased chloride permeability, and decreased P(Na)/P(Cl) and P(HCO3)/P(Cl). These findings constitute the first characterization of the permeability characteristics of claudins 6 and 9 in a cell model and may explain why the neonatal proximal tubule has lower permeability to chloride and higher resistance than the adult proximal tubule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.