ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Glutamate delta-1 receptors regulate a tonic excitatory conductance in the mouse bed nucleus of the stria terminalis and influence neuronal function.Psychopharmacology · 2026Article
- BNST specific mGlu5 receptor knockdown regulates sex-dependent expression of negative affect produced by adolescent ethanol exposure and adult stress.Translational psychiatry · 2021Article
- Adolescent alcohol exposure produces sex differences in negative affect-like behavior and group I mGluR BNST plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Metabotropic Glutamate Receptor Subtype 5 in Alcohol-Induced Negative Affect.Brain sciences · 2019Review
- Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Activated CaMKIIMolecular pharmacology · 2018Article
- Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors.ACS chemical neuroscience · 2018Article
- Metabotropic Glutamate Receptors in Alcohol Use Disorder: Physiology, Plasticity, and Promising Pharmacotherapies.ACS chemical neuroscience · 2018Article
- mGluNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Accumbens Mechanisms for Cued Sucrose Seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression.Journal of neuroscience research · 2016Article
- Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Mechanisms of Neuroplasticity and Ethanol's Effects on Plasticity in the Striatum and Bed Nucleus of the Stria Terminalis.Alcohol research : current reviews · 2015Article
- Biological substrates of addiction.Wiley interdisciplinary reviews. Cognitive science · 2014Review
- Contrasting distribution of physiological cell types in different regions of the bed nucleus of the stria terminalis.Journal of neurophysiology · 2013Article
- Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.The Journal of biological chemistry · 2013Article
- Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- New insights on neurobiological mechanisms underlying alcohol addiction.Neuropharmacology · 2013Review
- Regulation of the ventral tegmental area by the bed nucleus of the stria terminalis is required for expression of cocaine preference.The European journal of neuroscience · 2012Article
- mGluR-Dependent Synaptic Plasticity in Drug-Seeking.Frontiers in pharmacology · 2012Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Metabotropic glutamate receptor 5 (mGluR5) plays a critical role in psychostimulant-induced behavior, yet it is unclear whether mGluR5 is activated by psychostimulant administration, or whether its role is constitutive. We previously reported that activation of mGluR5 with the group I mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) can induce a long-term depression (DHPG-LTD) of glutamatergic transmission in the bed nucleus of the stria terminalis (BNST), and that ex vivo induction of this LTD is disrupted by repeated in vivo administration of cocaine. Here we demonstrate that DHPG-LTD is not maintained by alterations in glutamate release, and that postsynaptic endocytosis is necessary. Furthermore, we find that a single administration of cocaine produces a transient disruption of DHPG-LTD, and the duration of this disruption was increased by repeated days of cocaine administration. The disruption produced by cocaine was not permanent, because DHPG-LTD could be induced 10 d after cocaine administration. To test the role of mGluR5 in vivo in the cocaine-induced disruption of DHPG-LTD, we injected mice with the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine before cocaine. mGluR5 antagonism during in vivo cocaine administration rescued subsequent ex vivo induction of DHPG-LTD. The effects of in vivo cocaine could be mimicked by application of cocaine to BNST-containing slices, suggesting that the actions of cocaine are local. Thus, using a novel strategy of in vivo antagonist-induced rescue of ex vivo agonist effects for the same receptor, we provide evidence suggesting that mGluR5 activation is actively recruited by in vivo cocaine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.