ArticleThe Journal of biological chemistry2008
c-Fos activates glucosylceramide synthase and glycolipid synthesis in PC12 cells.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- In Situ Differential Analysis of α- and β-Glycosidase Activities in Lysosomes After Internalization Using Glucosylcerebroside-Based Liposomes.International journal of molecular sciences · 2026Article
- Identification of conserved gene expression changes across common glomerular diseases by spatial transcriptomics.Journal of nephrology · 2025Article
- Fra-1 and c-Fos N-Terminal Deletion Mutants Impair Breast Tumor Cell Proliferation by Blocking Lipid Synthesis Activation.Frontiers in oncology · 2019Article
- Lipid Metabolism in Neurons: A Brief Story of a Novel c-Fos-Dependent Mechanism for the Regulation of Their Synthesis.Frontiers in cellular neuroscience · 2019Review
- UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells.Cellular and molecular life sciences : CMLS · 2018Article
- The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1).BMC cancer · 2018Review
- Incorporation of Fluorescence Ceramide-Based HPLC Assay for Rapidly and Efficiently Assessing Glucosylceramide Synthase In Vivo.Scientific reports · 2017Article
- The Catalytic Efficiency of Lipin 1β Increases by Physically Interacting with the Proto-oncoprotein c-Fos.The Journal of biological chemistry · 2015Article
- Brain development is impaired in c-fos -/- mice.Oncotarget · 2015Article
- Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches.Frontiers in oncology · 2013Review
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- Controlling cytoplasmic c-Fos controls tumor growth in the peripheral and central nervous system.Neurochemical research · 2012Article
- A world of sphingolipids and glycolipids in the brain--novel functions of simple lipids modified with glucose.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Review
- c-Fos activates and physically interacts with specific enzymes of the pathway of synthesis of polyphosphoinositides.Molecular biology of the cell · 2011Article
- pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking.Molecular brain · 2010Article
- Roles of membrane trafficking in nerve repair and regeneration.Communicative & integrative biology · 2010Article
- Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.Journal of lipid research · 2010Article
- Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and mice.PloS one · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
It has been demonstrated that c-Fos has, in addition to its well recognized AP-1 transcription factor activity, the capacity to associate to the endoplasmic reticulum and activate key enzymes involved in the synthesis of phospholipids required for membrane biogenesis during cell growth and neurite formation. Because membrane genesis requires the coordinated supply of all its integral membrane components, the question emerges as to whether c-Fos also activates the synthesis of glycolipids, another ubiquitous membrane component. We show that c-Fos activates the metabolic labeling of glycolipids in differentiating PC12 cells. Specifically, c-Fos activates the enzyme glucosylceramide synthase (GlcCerS), the product of which, GlcCer, is the first glycosylated intermediate in the pathway of synthesis of glycolipids. By contrast, the activities of GlcCer galactosyltransferase 1 and lactosylceramide sialyltransferase 1 are essentially unaffected by c-Fos. Co-immunoprecipitation experiments in cells co-transfected with c-Fos and a V5-tagged version of GlcCerS evidenced that both proteins participate in a physical association. c-Fos expression is tightly regulated by specific environmental cues. This strict regulation assures that lipid metabolism activation will occur as a response to cell requirements thus pointing to c-Fos as an important regulator of key membrane metabolisms in membrane biogenesis-demanding processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.