ArticleRespiratory research2008
Association of mast cells with lung function in chronic obstructive pulmonary disease.
Article in Respiratory research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Immunohistochemical Analysis of Mastocyte Inflammation: A Comparative Study of COPD Associated with Tobacco Smoking and Wood Smoke Exposure.Biomedicines · 2025Article
- Differential expression of mast cells in the small airways and alveolar septa of current smokers and patients with small airway disease and COPD.ERJ open research · 2024Article
- Airway inflammatory changes in the lungs of patients with asthma-COPD overlap (ACO): a bronchoscopy endobronchial biopsy study.Respiratory research · 2023Article
- Increased mast cell activation in eosinophilic chronic obstructive pulmonary disease.Clinical & translational immunology · 2022Article
- Integrated analysis reveals lung fibrinogen gamma chain as a biomarker for chronic obstructive pulmonary disease.Annals of translational medicine · 2021Article
- Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD.International journal of chronic obstructive pulmonary disease · 2021Article
- Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis.The American journal of pathology · 2020Article
- The Role of Mast Cells in IgE-Independent Lung Diseases.Clinical reviews in allergy & immunology · 2020Review
- Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2018Review
- Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase.ACS medicinal chemistry letters · 2018Article
- Characterization, localization and comparison of c-Kit+ lung cells in never smokers and smokers with and without COPD.BMC pulmonary medicine · 2018Observational
- A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase.Pharmacology · 2018Article
- Role of mast cells in bronchial contraction in nonallergic obstructive lung pathology.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2017Article
- Mast cells in airway diseases and interstitial lung disease.European journal of pharmacology · 2016Review
- Article
- Histological characterization of mast cell chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease.Pulmonary circulation · 2014Article
- Cigarette smoke suppresses the surface expression of c-kit and FcεRI on mast cells.Mediators of inflammation · 2013Article
- Article
- Increased mast cell density and airway responses to allergic and non-allergic stimuli in a sheep model of chronic asthma.PloS one · 2012Article
- Airway mast cells in a rhesus model of childhood allergic airways disease.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in COPD and controls without airflow limitation, and determined their relation with lung function.
methodsLung tissue sections from 19 COPD patients (median [interquartile range] FEV1% predicted 56 [23-75]) and 10 controls were stained for tryptase and chymase. Numbers of MC-T and MC-C were determined in different regions of central and peripheral airways and percentage of degranulation was determined.
resultsCOPD patients had lower MC-T numbers in the subepithelial area of central airways than controls. In COPD, MC-T numbers in the airway wall and more specifically in the epithelium and subepithelial area of peripheral airways correlated positively with FEV1/VC (Spearman's rho (rs) 0.47, p = 0.05 and rs 0.48, p = 0.05, respectively); MC-C numbers in airway smooth muscle of peripheral airways correlated positively with FEV1% predicted (rs 0.57, p = 0.02). Both in COPD patients and controls the percentage of degranulated MC-T and MC-C mast cells was higher in peripheral than in central airways (all p < 0.05), but this was not different between the groups.
conclusionMore MC-T and MC-C in peripheral airways correlate with better lung function in COPD patients. It is yet to determine whether this reflects a protective association of mast cells with COPD pathogenesis, or that other explanations are to be considered.
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