Trial reportAddiction (Abingdon, England)2008
Psychological mediators of bupropion sustained-release treatment for smoking cessation.
Trial report in Addiction (Abingdon, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01120704 (Project 3), which is not on this map. Cited by 63 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Project 3: Identifying Optimal Strategies of Increasing Smokers' Adherence to Cessation Medications
Who cites it
63 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Possible New Symptoms of Tobacco Withdrawal III: Reduced Positive Affect-A Review and Meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Pooled it
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2020Pooled it
- Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Combined pharmacotherapy and behavioural interventions for smoking cessation.The Cochrane database of systematic reviews · 2016Pooled it
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2014Pooled it
- A systematic review of the relationships between craving and smoking cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Pooled it
- The clinical significance of drug craving.Annals of the New York Academy of Sciences · 2012Pooled it
- Time-varying mediated effects of the nicotine patch on smoking before and after a quit attempt when it is added to varenicline and counseling.Drug and alcohol dependence · 2026Trial
- Mediation Effects of Biobehavioral Factors in a Trial of Pharmacotherapy and Intensive Cessation Counseling for People with HIV Who Smoke Cigarettes in Nairobi, Kenya.AIDS and behavior · 2026Trial
- Reduced executive and reward connectivity is associated with smoking cessation response to repetitive transcranial magnetic stimulation: A double-blind, randomized, sham-controlled trial.Brain imaging and behavior · 2024Trial
- Understanding what changes adults in a smoking cessation study believe they need to make to quit smoking: A qualitative analysis of pre- and post-quit perceptions.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Trial
- Evaluating Treatment Mechanisms of Varenicline: Mediation by Affect and Craving.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Trial
- Comparative effects of varenicline or combination nicotine replacement therapy versus patch monotherapy on candidate mediators of early abstinence in a smoking cessation attempt.Addiction (Abingdon, England) · 2021Trial
- Time-varying effects of 'optimized smoking treatment' on craving, negative affect and anhedonia.Addiction (Abingdon, England) · 2021Trial
- Predictors of Smoking Cessation Attempts and Success Following Motivation-Phase Interventions Among People Initially Unwilling to Quit Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Smoking abstinence symptoms across 67 days compared with randomized controls-Moderation by nicotine replacement therapy, bupropion, and negative-affect traits.Experimental and clinical psychopharmacology · 2019Trial
- Effect of nicotine 6 mg gum on urges to smoke, a randomized clinical trial.BMC pharmacology & toxicology · 2019Trial
- Toward precision smoking cessation treatment II: Proximal effects of smoking cessation intervention components on putative mechanisms of action.Drug and alcohol dependence · 2017Trial
- Multilevel factor analysis of smokers' real-time negative affect ratings while quitting.Psychological assessment · 2016Trial
- A randomized clinical trial of a tailored behavioral smoking cessation preparation program.Behaviour research and therapy · 2016Trial
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
aimThe study aimed to test simultaneously our understanding of the effects of bupropion sustained-release (SR) treatment on putative mediators and our understanding of determinants of post-quit abstinence, including withdrawal distress, cigarette craving, positive affect and subjective reactions to cigarettes smoked during a lapse. The specificity of bupropion SR effects was also tested in exploratory analyses.
designData from a randomized, placebo-controlled clinical trial of bupropion SR were submitted to mediation analyses.
settingCenter for Tobacco Research and Intervention, Madison, WI, USA.
participantsA total of 403 adult, daily smokers without contraindications to bupropion SR use.
interventionParticipants were assigned randomly to receive a 9-week course of bupropion SR or placebo pill and to receive eight brief individual counseling sessions or no counseling. MEASUREMENTS: Ecological momentary assessment ratings of smoking behavior and putative mediators were collected pre- and post-quit.
findingsResults of structural equation and hierarchical linear models did not support the hypothesis that bupropion SR treatment improves short-term abstinence by reducing withdrawal distress or affecting the subjective effects of a lapse cigarette, but provided partial support for mediation by cigarette craving reduction and enhanced positive affect. Bupropion SR effects on point-prevalence abstinence at 1 month post-quit were also mediated partially by enhanced motivation to quit and self-efficacy.
conclusionsResults provided some support for models of bupropion SR treatment and relapse and suggested that motivational processes may partially account for bupropion SR efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.