Evidence map›Paper›PMID 18783406›Full record

ReviewClinical genetics2009

Finding genes underlying human disease.

C M Stein, R C Elston

Abstract readReview
In one paragraph

Review in Clinical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Genome-wide association mapping of flowering time inActa botanica Gallica : bulletin de la Societe botanique de France · 2013
    Article
  5. Article
  6. Article
  7. Article
  8. Genetic epidemiology of hip and knee osteoarthritis.Nature reviews. Rheumatology · 2011
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

C M SteinDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA. cmstein@cwru.edu
R C Elston

Funding

X-LINKED EXTENSION OF THE REVISED HASEMAN-ELSTON ALGORITHM FOR LINKAGE ANALYSISP41RR003655 · NCRR · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ELSTON, ROBERT C. · 1987 to 2011
$11.5M
Case Western Reserve University/Cleveland Clinic CTSA (KL2)KL2RR024990 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$9.5M
GENETIC ANALYSIS OF MULTIFACTORIAL TRAITSR37GM028356 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI ELSTON, ROBERT C. · 1998 to 2007
$2.9M
GENETIC ANALYSIS OF MULTIFACTORIAL TRAITSR01GM028356 · NIGMS · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI ELSTON, ROBERT C. · 1985 to 1997
–
NCRR NIH HHS KL2 RR024990NCRR NIH HHS KL2RR024990NCRR NIH HHS P41 RR003655NCRR NIH HHS RR03655NIGMS NIH HHS GM-28356NIGMS NIH HHS R01 GM028356NIGMS NIH HHS R37 GM028356PHS HHS P30CAD43703
6 · The paper itself

Abstract

With the surge in genome-wide association studies (GWAS), many have asked the question 'Are linkage studies dead?' In this article, we survey the approaches used in mapping human disease genes, reviewing the analysis strategies that preceded and laid the groundwork for GWAS. We note that earlier approaches are still useful and the development of new methodology is warranted.

Indexed as

Genetic Predisposition to DiseaseGenetic VariationGenome, HumanGenome-Wide Association StudyGenotypeHumansPolymorphism, Single Nucleotide

Identifiers

PMID18783406
PMCPMC3057167

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.