ReviewAdvances in experimental medicine and biology2008
Mitochondrial oscillations in physiology and pathophysiology.
Review in Advances in experimental medicine and biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed, 136 citations in OpenAlex.
- Delay Differential Equation Approach to Oligomerization Reveals the Delay Dynamics Underlying Oscillations in Mitochondrial Fission.Bulletin of mathematical biology · 2026Article
- Obstructive Sleep Apnea and Arrhythmia: A Narrative Review of Arrhythmogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2026Review
- Modelling brain metabolism with interacting nonautonomous phase oscillators.Frontiers in network physiology · 2026Article
- Heart Rate Variability Alterations During Delayed-Onset Muscle Soreness-Inducing Exercise-With Piezo2 Interpretation.Sports (Basel, Switzerland) · 2025Article
- Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling.Biophysical journal · 2023Article
- A dynamically coherent pattern of rhythms that matches between distant species across the evolutionary scale.Scientific reports · 2023Article
- BMP4 aggravates mitochondrial dysfunction of HRMECs.Heliyon · 2023Article
- Review
- Energy metabolism disturbance in migraine: From a mitochondrial point of view.Frontiers in physiology · 2023Review
- The Short-Term Opening of Cyclosporin A-Independent Palmitate/SrMembranes · 2022Article
- Adaptive behaviour and learning in slime moulds: the role of oscillations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.Scientific reports · 2021Article
- Propagation of Mitochondria-Derived Reactive Oxygen Species within theAntioxidants (Basel, Switzerland) · 2021Article
- Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis.Cells · 2020Review
- Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment.Aging cell · 2020Article
- Integrating Ultra-Weak Photon Emission Analysis in Mitochondrial Research.Frontiers in physiology · 2020Review
- PCSK9 inhibitor improves cardiac function and reduces infarct size in rats with ischaemia/reperfusion injury: Benefits beyond lipid-lowering effects.Journal of cellular and molecular medicine · 2019Article
- Temporal metabolic partitioning of the yeast and protist cellular networks: the cell is a global scale-invariant (fractal or self-similar) multioscillator.Journal of biomedical optics · 2018Article
- Computational Modeling of In Vitro Swelling of Mitochondria: A Biophysical Approach.Molecules (Basel, Switzerland) · 2018Article
- Effects of pulsing of light on the dentinogenesis of dental pulp stem cells in vitro.Scientific reports · 2018Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Oscillations in chemical reactions and metabolic pathways have historically served as prototypes for understanding the dynamics of complex nonlinear systems. This chapter reviews the oscillatory behavior of mitochondria, with a focus on the mitochondrial oscillator dependent on reactive oxygen species (ROS), as first described in heart cells. Experimental and theoretical evidence now indicates that mitochondrial energetic variables oscillate autonomously as part of a network of coupled oscillators under both physiological and pathological conditions. The physiological domain is characterized by small-amplitude oscillations in mitochondrial membrane potential (delta psi(m)) showing correlated behavior over a wide range of frequencies, as determined using Power Spectral Analysis and Relative Dispersion Analysis of long term recordings of delta psi(m). Under metabolic stress, when the balance between ROS generation and ROS scavenging is perturbed, the mitochondrial network throughout the cell locks to one main low-frequency, high-amplitude oscillatory mode. This behavior has major pathological implications because the energy dissipation and cellular redox changes that occur during delta psi(m) depolarization result in suppression of electrical excitability and Ca2+ handling, the two main functions of the cardiac cell. In an ischemia/reperfusion scenario these alterations scale up to the level of the whole organ, giving rise to fatal arrhythmias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.